PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
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Regulation of RhoA-dependent ROCKII activation by Shp2Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesisBile acids as metabolic regulatorsShp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defectsAllosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinasesSalicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 MutationsShp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellumFunctional short tandem repeat polymorphism of PTPN11 and susceptibility to hepatocellular carcinoma in Chinese populationsCoordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cellsProtein tyrosine phosphatases in the JAK/STAT pathwaySHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells.A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.Research progress of neuroblastoma related gene variations.Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuriaShp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.The molecular regulation of Janus kinase (JAK) activationDiverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromesSHP2E76K mutant promotes lung tumorigenesis in transgenic miceMultivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cellsTherapeutic potential of targeting the oncogenic SHP2 phosphatase.Genetic susceptibility on CagA-interacting molecules and gene-environment interaction with phytoestrogens: a putative risk factor for gastric cancer.Protein tyrosine phosphatases as potential therapeutic targets.Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.Shp2 suppresses PyMT-induced transformation in mouse fibroblasts by inhibiting Stat3 activity.A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factorInhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesisCritical role of Shp2 in tumor growth involving regulation of c-MycDeficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermisSPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancerTargeting a cryptic allosteric site for selective inhibition of the oncogenic protein tyrosine phosphatase Shp2Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burstGenetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76KNOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells.Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis.Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway.Shp2 function in hematopoietic stem cell biology and leukemogenesis.
P2860
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P2860
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
@ast
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
@en
type
label
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
@ast
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
@en
prefLabel
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
@ast
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
@en
P2860
P1433
P1476
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
@en
P2093
Gen-Sheng Feng
Rebecca J Chan
P2860
P304
P356
10.1182/BLOOD-2006-07-028829
P407
P577
2006-10-19T00:00:00Z