The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. - Wikidata - wikimedia - TriplyDB

The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.

The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.

http://www.wikidata.org/entity/Q35679564

about

USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC Mcl-1 ubiquitination: unique regulation of an essential survival protein.Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion.Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms.The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.Delving deeper: MCL-1's contributions to normal and cancer biology.Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15 The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.Programming cancer cells for high expression levels of Mcl1.Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.Tumour suppressive function of HUWE1 in thyroid cancer.HUWE1 interacts with PCNA to alleviate replication stress.Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death.Inverse association between MDM2 and HUWE1 protein expression levels in human breast cancer and liposarcoma.Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1.

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P2860

The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.

http://www.wikidata.org/entity/Q35679564

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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name

The E3 ubiquitin ligase Mule a ...... tain B lymphocyte homeostasis.

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The E3 ubiquitin ligase Mule a ...... tain B lymphocyte homeostasis.

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The E3 ubiquitin ligase Mule a ...... tain B lymphocyte homeostasis.

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The E3 ubiquitin ligase Mule a ...... tain B lymphocyte homeostasis.

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The E3 ubiquitin ligase Mule a ...... tain B lymphocyte homeostasis.

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The E3 ubiquitin ligase Mule a ...... tain B lymphocyte homeostasis.

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P1433

Journal of Experimental Medicine

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The E3 ubiquitin ligase Mule a ...... ntain B lymphocyte homeostasis

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P2093

Andrea Jurisicova

http://www.w3.org/2001/XMLSchema#string

Andrew Elia

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Andrew Wakeham

http://www.w3.org/2001/XMLSchema#string

Annick You-Ten

http://www.w3.org/2001/XMLSchema#string

Chiara Gorrini

http://www.w3.org/2001/XMLSchema#string

Claire Hong

http://www.w3.org/2001/XMLSchema#string

Elias Hobeika

http://www.w3.org/2001/XMLSchema#string

Gordon S Duncan

http://www.w3.org/2001/XMLSchema#string

Han You

http://www.w3.org/2001/XMLSchema#string

Jacqui Detmar

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones.

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

Immunoglobulin class switch recombination is impaired in Atm-deficient mice

B cell differentiation and isotype switching is related to division cycle number

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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173-186

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scholarly article

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10.1084/JEM.20111363

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P433

1

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209

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Pamela S Ohashi

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2012-01-02T00:00:00Z

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249963761

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22213803

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3260869

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