Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling
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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasisInhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin.Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.Expression of Girdin in primary hepatocellular carcinoma and its effect on cell proliferation and invasion.GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomyIntegrins activate trimeric G proteins via the nonreceptor protein GIV/GirdinGαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin).Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein ActivationProtein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/GirdinGIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.Translocation of activator of G-protein signaling 3 to the Golgi apparatus in response to receptor activation and its effect on the trans-Golgi network.GIV/Girdin activates Gαi and inhibits Gαs via the same motifAMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.The untapped potential of tyrosine-based G protein signaling.A chimeric antibody targeting CD147 inhibits hepatocellular carcinoma cell motility via FAK-PI3K-Akt-Girdin signaling pathway.GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.The Gαi-GIV binding interface is a druggable protein-protein interactionBiochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling.A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins
P2860
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P2860
Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling
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2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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name
Functional characterization of ...... threshold effect in signaling
@ast
Functional characterization of ...... threshold effect in signaling
@en
type
label
Functional characterization of ...... threshold effect in signaling
@ast
Functional characterization of ...... threshold effect in signaling
@en
prefLabel
Functional characterization of ...... threshold effect in signaling
@ast
Functional characterization of ...... threshold effect in signaling
@en
P2093
P2860
P356
P1476
Functional characterization of ...... threshold effect in signaling
@en
P2093
Michelle A Adia
Mikel Garcia-Marcos
Patrick S Kietrsunthorn
Pradipta Ghosh
Yelena Pavlova
P2860
P304
P356
10.1073/PNAS.1120538109
P407
P577
2012-01-25T00:00:00Z