Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.
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Current Insights into Molecular Mechanisms of Alzheimer Disease and Their Implications for Therapeutic ApproachesThe presenilinsThe metal-binding properties of DREAM: evidence for calcium-mediated changes in DREAM structure.Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signalingPresenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 productionThe multiple paradoxes of presenilins.Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory.Presenilin function and gamma-secretase activity.Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing.Early onset Alzheimer's disease and oxidative stress.Protein Phosphorylation is a Key Mechanism in Alzheimer's Disease.Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.Identification and characterization of presenilin-independent Notch signaling.The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins.A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2.Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.Identification of gamma-secretase inhibitor potency determinants on presenilin.Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.A novel mutation in the PSEN1 gene (L286P) associated with familial early-onset dementia of Alzheimer type and lobar haematomas.
P2860
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P2860
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.
description
2000 nî lūn-bûn
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2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
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2000年论文
@zh-cn
name
Separation of presenilin funct ...... and endoproteolysis of Notch.
@ast
Separation of presenilin funct ...... and endoproteolysis of Notch.
@en
type
label
Separation of presenilin funct ...... and endoproteolysis of Notch.
@ast
Separation of presenilin funct ...... and endoproteolysis of Notch.
@en
prefLabel
Separation of presenilin funct ...... and endoproteolysis of Notch.
@ast
Separation of presenilin funct ...... and endoproteolysis of Notch.
@en
P2093
P2860
P356
P1476
Separation of presenilin funct ...... and endoproteolysis of Notch.
@en
P2093
Baumeister R
Multhaup G
P2860
P304
P356
10.1073/PNAS.100049897
P407
P577
2000-05-01T00:00:00Z