Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.
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Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunctionThe role of deubiquitinating enzymes in synaptic function and nervous system diseasesProtein degradation and protein synthesis in long-term memory formation.Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 FunctionThe ataxia (axJ) mutation causes abnormal GABAA receptor turnover in miceUbiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformationUCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagyExcess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1Recognition and processing of ubiquitin-protein conjugates by the proteasomeThe ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation.Mass spectrometry assessment of ubiquitin carboxyl-terminal hydrolase L1 partitioning between soluble and particulate brain homogenate fractionsUbiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junctionOverexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine clusterGenetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14)Ubiquitination in postsynaptic function and plasticityUbiquitin homeostasis is critical for synaptic development and functionAltered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14.Ubiquitin C-terminal hydrolase l1 in tumorigenesisUsp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits.Absence of UCHL 1 function leads to selective motor neuropathy.Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctionsOxidative protein damage and the proteasome.Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1.Cellular ubiquitin pool dynamics and homeostasis.UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein.Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury.Coordination of synaptic vesicle trafficking and turnover by the Rab35 signaling network.Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.Meddling with Fate: The Proteasomal Deubiquitinating Enzymes.USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
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P2860
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 15 August 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Differential effects of Usp14 ...... system and synaptic activity.
@en
Differential effects of Usp14 ...... system and synaptic activity.
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type
label
Differential effects of Usp14 ...... system and synaptic activity.
@en
Differential effects of Usp14 ...... system and synaptic activity.
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prefLabel
Differential effects of Usp14 ...... system and synaptic activity.
@en
Differential effects of Usp14 ...... system and synaptic activity.
@nl
P2093
P2860
P1476
Differential effects of Usp14 ...... e system and synaptic activity
@en
P2093
A P Taylor
D G Schroeder
H L Ploegh
J A Wilson
K Artavanis-Tsakonas
S L Campbell
S M Wilson
P2860
P304
P356
10.1016/J.MCN.2008.07.028
P577
2008-08-15T00:00:00Z