Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. - Wikidata - wikimedia - TriplyDB

Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.

Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.

http://www.wikidata.org/entity/Q37314768

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A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2 Functional Significance of Aurora Kinases-p53 Protein Family Interactions in Cancer Transcriptional control of mitosis: deregulation and cancer Aurora-A kinase is essential for bipolar spindle formation and early development Phase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.Danusertib, an aurora kinase inhibitor.The aurora kinases in cell cycle and leukemia TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitis Genetic background influences loss of heterozygosity patterns in radiation-induced mouse thymic lymphoma.Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation.p53-Aurora A mitotic feedback loop regulates cell cycle progression and genomic stability.Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.Aurora A kinase (AURKA) in normal and pathological cell division.Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells.Aurora kinase inhibitors: identification and preclinical validation of their biomarkers.Cell cycle-dependent ciliogenesis and cancer Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice Aurora kinase inhibitor PHA-739358 suppresses growth of hepatocellular carcinoma in vitro and in a xenograft mouse model.A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors.Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.ENMD-2076 for hematological malignancies.Primary cilia: highly sophisticated biological sensors.Aurora-A: a potential DNA repair modulator.Kinase signaling and targeted therapy for primary myelofibrosis.Clinical Development of Anti-mitotic Drugs in Cancer.Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53 A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines.Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells.The RP-p53-Mdm2 pathway: a new link to genetic integrity?p53, transcriptional, and drug sensitivity: fresh perspectives on an old activity.

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Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.

http://www.wikidata.org/entity/Q37314768

description

article científic

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article scientifique

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articolo scientifico

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bilimsel makale

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scientific article published on February 2007

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Crosstalk between Aurora-A and ...... in tumors from p53 null mice.

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Crosstalk between Aurora-A and ...... in tumors from p53 null mice.

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Crosstalk between Aurora-A and ...... in tumors from p53 null mice.

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Crosstalk between Aurora-A and ...... in tumors from p53 null mice.

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Crosstalk between Aurora-A and ...... in tumors from p53 null mice.

@en

Crosstalk between Aurora-A and ...... in tumors from p53 null mice.

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J.CCR.2006.11.025

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Crosstalk between Aurora-A and ...... in tumors from p53 null mice.

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Allan Balmain

http://www.w3.org/2001/XMLSchema#string

Di Wu

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Jesus Perez-Losada

http://www.w3.org/2001/XMLSchema#string

Joe W Gray

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Qian Li

http://www.w3.org/2001/XMLSchema#string

Richard M Neve

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Tao Jiang

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Wei-Wen Cai

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10.1016/J.CCR.2006.11.025

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