Early mammalian erythropoiesis requires the Dot1L methyltransferase - Wikidata - wikimedia - TriplyDB

Early mammalian erythropoiesis requires the Dot1L methyltransferase

Early mammalian erythropoiesis requires the Dot1L methyltransferase

http://www.wikidata.org/entity/Q35876889

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A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives The many faces of histone H3K79 methylation Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats The molecular mechanics of mixed lineage leukemia.AF10 plays a key role in the survival of uncommitted hematopoietic cells.Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.DOT1L regulates dystrophin expression and is critical for cardiac function.Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes.MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing.The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins.Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.The modern primitives: applying new technological approaches to explore the biology of the earliest red blood cells Epigenetics of hematopoiesis and hematological malignancies.Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.The diverse functions of Dot1 and H3K79 methylation.Histone methylation in myelodysplastic syndromes.The role of chromatin modifiers in normal and malignant hematopoiesis Epigenetic and genetic mechanisms in red cell biology.Epigenetics in the hematologic malignancies.The upstreams and downstreams of H3K79 methylation by DOT1L.SETD4 Regulates Cell Quiescence and Catalyzes the Trimethylation of H4K20 during Diapause Formation in Artemia.Targeting human SET1/MLL family of proteins.

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P2860

Early mammalian erythropoiesis requires the Dot1L methyltransferase

http://www.wikidata.org/entity/Q35876889

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Early mammalian erythropoiesis requires the Dot1L methyltransferase

@ast

Early mammalian erythropoiesis requires the Dot1L methyltransferase

@en

type

label

Early mammalian erythropoiesis requires the Dot1L methyltransferase

@ast

Early mammalian erythropoiesis requires the Dot1L methyltransferase

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prefLabel

Early mammalian erythropoiesis requires the Dot1L methyltransferase

@ast

Early mammalian erythropoiesis requires the Dot1L methyltransferase

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Early mammalian erythropoiesis requires the Dot1L methyltransferase

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P2093

Jay L Vivian

http://www.w3.org/2001/XMLSchema#string

Jennifer B Jacob

http://www.w3.org/2001/XMLSchema#string

Jessica N Copeland

http://www.w3.org/2001/XMLSchema#string

Mingcai Zhang

http://www.w3.org/2001/XMLSchema#string

Patrick E Fields

http://www.w3.org/2001/XMLSchema#string

Timothy A Fields

http://www.w3.org/2001/XMLSchema#string

Yanping Yang

http://www.w3.org/2001/XMLSchema#string

Yi Feng

http://www.w3.org/2001/XMLSchema#string

P2860

The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.

Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure

Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase

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4483-4491

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scholarly article

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10.1182/BLOOD-2010-03-276501

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22

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116

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Manoela Marques Ortega

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2010-08-26T00:00:00Z

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46009463

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20798234

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3321834

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