Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
about
Epigenetics of epithelial Na(+) channel-dependent sodium uptake and blood pressure regulationRegulation of αENaC transcriptionEpigenetics and the control of the collecting duct epithelial sodium channelCharacterization of the DOT1L network: implications of diverse roles for DOT1LSLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressorCREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells.Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis.Aldosterone-sensitive repression of ENaCalpha transcription by a histone H3 lysine-79 methyltransferaseSpironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic ratsDot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner.Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.Widely expressed Af17 is likely not required for embryogenesis, hematopoiesis, and animal survival.Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alphaNew mechanisms for transcriptional repression of ENaC And iNOS.Early mammalian erythropoiesis requires the Dot1L methyltransferaseA role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.Aqp2-expressing cells give rise to renal intercalated cells.Epigenetics and the control of epithelial sodium channel expression in collecting duct.Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct.AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha.Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development.A modified epigenetics toolbox to study histone modifications on the nucleosome core.The diverse functions of Dot1 and H3K79 methylation.The upstreams and downstreams of H3K79 methylation by DOT1L.Development and Diseases of the Collecting Duct System.Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice.Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression.
P2860
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P2860
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
description
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Februar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/02/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/02/01)
@nl
наукова стаття, опублікована в лютому 2004
@uk
مقالة علمية (نشرت في فبراير 2004)
@ar
name
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@ast
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@en
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@nl
type
label
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@ast
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@en
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@nl
prefLabel
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@ast
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@en
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@nl
P2860
P356
P1433
P1476
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
@en
P2093
Bruce C. Kone
Wenzheng Zhang
P2860
P304
P356
10.1042/BJ20030839
P407
P577
2004-02-01T00:00:00Z