Controlling murine and rat chronic pain through A3 adenosine receptor activation - Wikidata - wikimedia - TriplyDB

Controlling murine and rat chronic pain through A3 adenosine receptor activation

Controlling murine and rat chronic pain through A3 adenosine receptor activation

http://www.wikidata.org/entity/Q35913037

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Potential for developing purinergic drugs for gastrointestinal diseases Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners Adenosine receptors as drug targets--what are the challenges?The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy.Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain.Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.Metabolic mapping of A3 adenosine receptor agonist MRS5980 Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine.Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.Cancer and orofacial pain.The purinergic system and glial cells: emerging costars in nociception.Caffeine as an opioid analgesic adjuvant in fibromyalgia A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.Adenosine A3 receptor agonists: do recent findings offer new hope in chronic pain treatment?A binding kinetics study of human adenosine A3 receptor agonists.Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.Highly selective A3 adenosine receptor agonists relieve chronic neuropathic pain.Role of A3 adenosine receptor in diabetic neuropathy.Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source.

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Controlling murine and rat chronic pain through A3 adenosine receptor activation

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Controlling murine and rat chronic pain through A3 adenosine receptor activation

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Collin Chen

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Daniela Salvemini

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Kali Janes

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Leesa Bryant

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Zhoumou Chen

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P2860

Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer

The Epidemiology of Chronic Pain of Predominantly Neuropathic Origin. Results From a General Population Survey

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists

2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors

Adenosine A3 receptors are located in neurons of the rat hippocampus

Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis: data from a phase II clinical trial.

Dual purinergic synaptic transmission in the human enteric nervous system.

Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.

The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells

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