Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation.
about
Current and future alternative therapies for beta-thalassemia majorNovel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathwayNuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia.Histone acetylation at the human beta-globin locus changes with developmental age.Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobinMi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.β-Thalassemia due to intronic LINE-1 insertion in the β-globin gene (HBB): molecular mechanisms underlying reduced transcript levels of the β-globin(L1) alleleEpigenetics of beta-globin gene regulationCis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells.A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci.Role of stem cell factor in the reactivation of human fetal hemoglobin.Ex-vivo expansion of red blood cells: how real for transfusion in humans?Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.Osterix and NO66 histone demethylase control the chromatin of Osterix target genes during osteoblast differentiation.SIRT1 activates the expression of fetal hemoglobin genesEpigenetic dysregulation of the erythropoietic transcription factor KLF1 and the beta-like globin locus in juvenile myelomonocytic leukemia.Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the human beta-globin locus.Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiationExtensively self-renewing erythroblasts derived from transgenic β-yac mice is a novel model system for studying globin switching and erythroid maturation.Fetal haemoglobin induction in sickle cell disease.A Genetic Variant Ameliorates β-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression.The intrinsic genetic and epigenetic regulator factors as therapeutic targets, and the effect on fetal globin gene expression.Fetal Hemoglobin Induction by Epigenetic Drugs
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P2860
Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Developmental- and differentia ...... obin promoter DNA methylation.
@ast
Developmental- and differentia ...... obin promoter DNA methylation.
@en
type
label
Developmental- and differentia ...... obin promoter DNA methylation.
@ast
Developmental- and differentia ...... obin promoter DNA methylation.
@en
prefLabel
Developmental- and differentia ...... obin promoter DNA methylation.
@ast
Developmental- and differentia ...... obin promoter DNA methylation.
@en
P2093
P2860
P1433
P1476
Developmental- and differentia ...... obin promoter DNA methylation.
@en
P2093
Christine A Richardson
Christopher H Lowrey
Kristin Johnson
Rodwell Mabaera
Steven Fiering
P2860
P304
P356
10.1182/BLOOD-2007-01-068635
P407
P577
2007-04-24T00:00:00Z