The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. - Wikidata - wikimedia - TriplyDB

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

http://www.wikidata.org/entity/Q35944646

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Evidence that dynamin-2 functions as a signal-transducing GTPase Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter Role of MDM2 and MDMX in DNA repair Cancer predisposition caused by elevated mitotic recombination in Bloom mice Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2 Therapeutic considerations for Mdm2: not just a one trick pony Mdm2: the ups and downs.Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis.Decreased Mdm2 expression inhibits tumor development and extends survival independent of Arf and dependent on p53.JNK targets p53 ubiquitination and degradation in nonstressed cells.Phosphorylation of serine 18 regulates distinct p53 functions in mice Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency.MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice.Transgenic rescue of ataxia mice reveals a male-specific sterility defect.p53 regulates mtDNA copy number and mitocheckpoint pathway.The Zn-finger domain of MdmX suppresses cancer progression by promoting genome stability in p53-mutant cells.Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis.Mdm2 and MdmX as Regulators of Gene Expression Lack of p53 induction in fish cells by model chemotherapeutics.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes.An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.p53: only ARF the story.

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P2860

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

http://www.wikidata.org/entity/Q35944646

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1996 nî lūn-bûn

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The tumorigenic potential and ...... e presence or absence of Mdm2.

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Proceedings of the National Academy of Sciences of the United States of America

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The tumorigenic potential and ...... e presence or absence of Mdm2.

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P2093

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P2860

Interaction between the retinoblastoma protein and the oncoprotein MDM2

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

Amplification of a gene encoding a p53-associated protein in human sarcomas

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

The p53-mdm-2 autoregulatory feedback loop

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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