Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.
about
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant functionRegulation of glucose metabolism by p53: emerging new roles for the tumor suppressorDNA repair and aging: the impact of the p53 familySenescence in adipose-derived stem cells and its implications in nerve regenerationAging and radiation: bad companionsAging-Induced Stem Cell Mutations as Drivers for Disease and CancerGrowth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocationsEnhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts.Germline mutations and polymorphisms in the origins of cancers in women.Ionizing radiation and aging: rejuvenating an old idea.Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice.Pathologies associated with the p53 response.Negative regulation of tumor suppressor p53 by microRNA miR-504Paradoxical suppression of cellular senescence by p53mTOR favors senescence over quiescence in p53-arrested cells.P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue.Tissue-specific and age-dependent effects of global Mdm2 lossGlutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress.Bladder cancer in the elderly: clinical outcomes, basic mechanisms, and future research direction.Interaction between the Cockayne syndrome B and p53 proteins: implications for agingUnfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?Limiting the power of p53 through the ubiquitin proteasome pathway.Autophagy and ageing: implications for age-related neurodegenerative diseases.Do DNA Double-Strand Breaks Drive Aging?Senescence and apoptosis: dueling or complementary cell fates?New plays in the p53 theater.Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors.A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activityElevated estrogen receptor-α in VHL-deficient condition induces microtubule organizing center amplification via disruption of BRCA1/Rad51 interaction.Reversing the aging stromal phenotype prevents carcinoma initiationMitochondrial dysfunction impairs tumor suppressor p53 expression/function.Inflammation and p53: A Tale of Two StressesThe Regulation of Aging and Longevity: A New and Complex Role of p53.The anti-hypercholesterolemic effect of low p53 expression protects vascular endothelial function in miceA single whole-body low dose X-irradiation does not affect L1, B1 and IAP repeat element DNA methylation longitudinallyAging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expressionHeightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in miceHormesis does not make sense except in the light of TOR-driven aging.
P2860
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P2860
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Declining p53 function in the ...... ncidence in older populations.
@ast
Declining p53 function in the ...... ncidence in older populations.
@en
type
label
Declining p53 function in the ...... ncidence in older populations.
@ast
Declining p53 function in the ...... ncidence in older populations.
@en
prefLabel
Declining p53 function in the ...... ncidence in older populations.
@ast
Declining p53 function in the ...... ncidence in older populations.
@en
P2093
P2860
P50
P356
P1476
Declining p53 function in the ...... ncidence in older populations.
@en
P2093
Angelika K Teresky
Eva Hernando
Zhaohui Feng
P2860
P304
16633-16638
P356
10.1073/PNAS.0708043104
P407
P577
2007-10-05T00:00:00Z