Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens.
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Harnessing the protective potential of HIV-1 neutralizing antibodiesTrimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and GProtein stability: a crystallographer's perspectiveImmunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing EpitopesLessons learned from human HIV vaccine trials.Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope GlycoproteinHIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies.Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP TrimersSequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization BreadthCross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library.Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer.Native Conformation and Canonical Disulfide Bond Formation Are Interlinked Properties of HIV-1 Env Glycoproteins.Range of CD4-Bound Conformations of HIV-1 gp120, as Defined Using Conditional CD4-Induced Antibodies.Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticlesUncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates.Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.Native-like Env trimers as a platform for HIV-1 vaccine design.Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies.Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers.An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies.Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoproteinNew developments in an old strategy: heterologous vector primes and envelope protein boosts in HIV vaccine design.Approaches to the induction of HIV broadly neutralizing antibodies.Evolution of B cell analysis and Env trimer redesign.The HIV-1 envelope glycoprotein structure: nailing down a moving target.Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble TrimersCryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimerImproving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers.Characterization of a stable HIV-1 B/C recombinant, soluble and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes.CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface.Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers.Time-course, negative-stain electron microscopy-based analysis for investigating protein-protein interactions at the single-molecule level.High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers.HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.Immunogenicity in rabbits of SOSIP trimers from clades A, B and C, given individually, sequentially or in combinations.
P2860
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P2860
Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
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2015年學術文章
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2015年學術文章
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name
Design and structure of two HI ...... of native-like Env immunogens.
@ast
Design and structure of two HI ...... of native-like Env immunogens.
@en
type
label
Design and structure of two HI ...... of native-like Env immunogens.
@ast
Design and structure of two HI ...... of native-like Env immunogens.
@en
prefLabel
Design and structure of two HI ...... of native-like Env immunogens.
@ast
Design and structure of two HI ...... of native-like Env immunogens.
@en
P2093
P2860
P356
P1476
Design and structure of two HI ...... of native-like Env immunogens.
@en
P2093
Alba Torrents de la Peña
Albert Cupo
Andrew B Ward
Anila Yasmeen
Gabriel Ozorowski
Ian A Wilson
John P Moore
Michael Golabek
P J Klasse
Pavel Pugach
P2860
P304
11947-11952
P356
10.1073/PNAS.1507793112
P407
P577
2015-09-08T00:00:00Z