Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells - Wikidata - wikimedia - TriplyDB

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

http://www.wikidata.org/entity/Q36139561

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FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2 Is the Canonical RAF/MEK/ERK Signaling Pathway a Therapeutic Target in SCLC?Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration.Weighted similarity-based clustering of chemical structures and bioactivity data in early drug discovery.Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress Raf-1 activation prevents caspase 9 processing downstream of apoptosome formation.Dysregulation of janus kinases and signal transducers and activators of transcription in cancer.Osmostress-induced apoptosis in Xenopus oocytes: role of stress protein kinases, calpains and Smac/DIABLO.Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress.Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.Caspase family proteases and apoptosis.RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation.The role of mitochondria in apoptosis*.Multifaceted targeting in cancer: the recent cell death players meet the usual oncogene suspects.The herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation.Protein kinase C epsilon: an oncogene and emerging tumor biomarker.XIAP 3'-untranslated region as a ceRNA promotes FSCN1 function in inducing the progression of breast cancer by binding endogenous miR-29a-5p.Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy.Fibroblast growth factors and their receptors in cancer.S6K2: The Neglected S6 Kinase Family Member.Stephania Tetrandra and Ginseng-Containing Chinese Herbal Formulation NSENL Reverses Cisplatin Resistance in Lung Cancer Xenografts.hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases.Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells.Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis.Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer.MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm.Fibroblast growth factor-10 prevents asbestos-induced alveolar epithelial cell apoptosis by a mitogen-activated protein kinase-dependent mechanism.Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics.Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death.Growth factor mediated signaling in pancreatic pathogenesis Drug resistance in cancer.Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis.A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells.Emerging roles of hnRNPA1 in modulating malignant transformation.

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Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

http://www.wikidata.org/entity/Q36139561

description

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Fibroblast growth factor 2-med ...... n small cell lung cancer cells

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Fibroblast growth factor 2-med ...... n small cell lung cancer cells

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Fibroblast growth factor 2-med ...... n small cell lung cancer cells

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MCB.23.21.7600-7610.2003

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Molecular and Cellular Biology

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Fibroblast growth factor 2-med ...... n small cell lung cancer cells

@en

P2093

Adeline Lesay

http://www.w3.org/2001/XMLSchema#string

Alexandre Arcaro

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Bee Ling Ng

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Huseyin Mehmet

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Michael J Seckl

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Nicholas R Lemoine

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Olivier E Pardo

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Patricia H Warne

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Rita Lopes

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Teresa D Tetley

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P2860

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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7600-7610

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10.1128/MCB.23.21.7600-7610.2003

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21

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Julian Downward

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2003-11-01T00:00:00Z

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14560006

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207633

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