Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule.
about
Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivThe peptide-specific alloreactive human T cell repertoire varies largely between individuals and is not extended in HLA-A*0205--anti-HLA-A*0201 pairings.Alloreactivity: an old puzzle revisited.Negative selection imparts peptide specificity to the mature T cell repertoire.Alloreactive cytotoxic T lymphocytes recognize epitopes determined by both the alpha helices and beta sheets of the class I peptide binding site.Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cellsDual HLA class I and class II restricted recognition of alloreactive T lymphocytes mediated by a single T cell receptor complex.TL antigen as a transplantation antigen recognized by TL-restricted cytotoxic T cellsPeptide-independent recognition by alloreactive cytotoxic T lymphocytes (CTL).A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.Single-residue changes in class I major histocompatibility complex molecules stimulate responses to self peptidesHLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele mismatched hematopoietic cell transplants from unrelated donors.HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.Allopeptides and the alloimmune response.In vitro peptide binding to the heavy chain of the class I molecule of the major histocompatibility complex molecule HLA-A2.Alloreactive T cells discriminate among a diverse set of endogenous peptides.Activation of a T cell hybridoma by an alloligand results in differential effects on IL-2 secretion and activation-induced cell death.The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules.Alloreactive cytotoxic T-cell function, peptide nonspecific.T cell receptor (TCR) repertoire in alloimmune responses.On the nature of peptides involved in T cell alloreactivity.Comparison of TCR-alpha beta sequences of cross-reactive anti-DR alloreactive T-cell clones: identification of possible contact residues based on charge complementarity between TCR chains and DR determinants.Monte Carlo study of the effect of beta 2-microglobulin on the binding cleft of the HLA-A2 complex.A similarity in peptide cross-reactivity between alloantigen- and nominal antigen-induced CD8+ T cell responses in vitro.Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry.Memory alloreactive cytotoxic T cells do not require costimulation for activation in vitro.The epitope detected by cytotoxic T lymphocytes against thymus leukemia (TL) antigen is TAP independent.
P2860
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P2860
Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule.
description
1990 nî lūn-bûn
@nan
1990 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Cytotoxic T lymphocytes recogn ...... an allogeneic target molecule.
@ast
Cytotoxic T lymphocytes recogn ...... an allogeneic target molecule.
@en
type
label
Cytotoxic T lymphocytes recogn ...... an allogeneic target molecule.
@ast
Cytotoxic T lymphocytes recogn ...... an allogeneic target molecule.
@en
prefLabel
Cytotoxic T lymphocytes recogn ...... an allogeneic target molecule.
@ast
Cytotoxic T lymphocytes recogn ...... an allogeneic target molecule.
@en
P2860
P356
P1476
Cytotoxic T lymphocytes recogn ...... an allogeneic target molecule.
@en
P2093
T J Elliott
P2860
P304
P356
10.1073/PNAS.87.13.5213
P407
P577
1990-07-01T00:00:00Z