Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.
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Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell linesAssignment of the human dihydrofolate reductase gene to the q11----q22 region of chromosome 5Intronless human dihydrofolate reductase genes are derived from processed RNA moleculesDifferent Facets of Copy Number Changes: Permanent, Transient, and AdaptiveMethotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.Amplification and cloning of the Chinese hamster glutamine synthetase gene.Gene-amplification model of carcinogenesis.On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.Resistance to antifolates.Structure of the dihydrofolate reductase gene in Chinese hamster ovary cellsAmplified dihydrofolate reductase genes are located in chromosome regions containing DNA that replicates during the first half of S-phase.Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes.A study of chromosomal changes associated with amplified dihydrofolate reductase genes in rat hepatoma cells and their dedifferentiated variantsGene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in cultureAmplified DNA sequences in Y1 mouse adrenal tumor cells: association with double minutes and localization to a homogeneously staining chromosomal region.Gene amplification in Rhynchosciara salivary gland chromosomes.Selective amplification of polymorphic dihydrofolate reductase gene loci in Chinese hamster lung cells.Gene amplification in methotrexate-resistant mouse cells. IV. Different DNA sequences are amplified in different resistant lines.General method for cloning amplified DNA by differential screening with genomic probesUnstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification.Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyureaUV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.Amplification and expression of human alpha-globin genes in Chinese hamster ovary cells.Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell lineRelationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiationOverproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.Mathematical modeling of folate metabolism.Expression and characterization of the product of a human immune interferon cDNA gene in Chinese hamster ovary cells.Specific DNA sequence amplification in human neuroblastoma cellsLoss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyureaGene amplification: an example of accelerated evolution in tumorigenic cellsQuantitative correlation of homogeneously stained regions on chromosome 10 with dihydrofolate reductase enzyme in human cells.Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line
P2860
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P2860
Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
1979年论文
@zh
1979年论文
@zh-cn
name
Correlation of dihydrofolate r ...... osomal region in L5178Y cells.
@ast
Correlation of dihydrofolate r ...... osomal region in L5178Y cells.
@en
type
label
Correlation of dihydrofolate r ...... osomal region in L5178Y cells.
@ast
Correlation of dihydrofolate r ...... osomal region in L5178Y cells.
@en
prefLabel
Correlation of dihydrofolate r ...... osomal region in L5178Y cells.
@ast
Correlation of dihydrofolate r ...... osomal region in L5178Y cells.
@en
P2093
P2860
P356
P1476
Correlation of dihydrofolate r ...... osomal region in L5178Y cells.
@en
P2093
Berenson RJ
Bertino JR
Dolnick BJ
Kaufman RJ
Nunberg JH
Schimke RT
P2860
P304
P356
10.1083/JCB.83.2.394
P407
P433
P577
1979-11-01T00:00:00Z