Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture - Wikidata - wikimedia - TriplyDB

Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture

Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture

http://www.wikidata.org/entity/Q36259766

about

Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates.Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo.Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometry Polyglutamation of methotrexate. Is methotrexate a prodrug?Update on trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties.Gene amplification: an example of accelerated evolution in tumorigenic cells Alkylating agent resistance: in vitro studies with human cell lines.DNA amplification is rare in normal human cells.Environmental change drives accelerated adaptation through stimulated copy number variation.Congruence of SQM1 protein expression with methotrexate sensitivity and transport.Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia.Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines.Mechanism of methotrexate-sensitivity of choriocarcinoma cells in culture.Reversal of methotrexate cytotoxicity to human bone marrow cells and leukemic K562 cells by leucovorin: methotrexate polyglutamates formation as a possible important factor.

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P2860

Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture

http://www.wikidata.org/entity/Q36259766

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1984 nî lūn-bûn

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1984年学术文章

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Proceedings of the National Academy of Sciences of the United States of America

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Development of methotrexate re ...... f the head and neck in culture

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A Rosowsky

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C A Cucchi

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E Frei

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P2860

Protein measurement with the Folin phenol reagent

Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines

Intronless human dihydrofolate reductase genes are derived from processed RNA molecules

Detection of specific sequences among DNA fragments separated by gel electrophoresis

Isolation and characterization of a human locus homologous to the transforming gene (v-fes) of feline sarcoma virus.

A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA.

Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.

Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.

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2873-2877

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10.1073/PNAS.81.9.2873

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9

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81

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William A. Haseltine

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16994132

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6201865

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