Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization.
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The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1Identification of amino acid residues within the C terminus of the Glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane.Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles.Spatial compartmentalization of signal transduction in insulin action.Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblastsPhosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter.Isoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding.G(alpha)11 signaling through ARF6 regulates F-actin mobilization and GLUT4 glucose transporter translocation to the plasma membrane.The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesiclesTyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.GLUT4 exocytosis.Identification of the carboxy terminus as important for the isoform-specific subcellular targeting of glucose transporter proteins.The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domainA double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal.Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4.Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail.Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes.Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment.Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.Analysis of the structural features of the C-terminus of GLUT1 that are required for transport catalytic activity.ATP-sensitive binding of a 70-kDa cytosolic protein to the glucose transporter in rat adipocytes.Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter.Ethanol Enhances TGF-β Activity by Recruiting TGF-β Receptors From Intracellular Vesicles/Lipid Rafts/Caveolae to Non-Lipid Raft Microdomains.Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrationsMuscling in on GLUT4 kinetics.Molecular mechanisms controlling GLUT4 intracellular retention.Hormonal regulation of the insulin-responsive glucose transporter, GLUT4: some recent advances.Expression of the liver-type glucose transporter (GLUT2) in 3T3-L1 adipocytes: analysis of the effects of insulin on subcellular distribution.Possible domains responsible for intracellular targeting and insulin-dependent translocation of glucose transporter type 4.Subcellular trafficking kinetics of GLU4 mutated at the N- and C-terminal.A synthetic peptide corresponding to the GLUT4 C-terminal cytoplasmic domain causes insulin-like glucose transport stimulation and GLUT4 recruitment in rat adipocytes.Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling.Molecular basis of insulin-responsive GLUT4 trafficking systems revealed by single molecule imaging.Rapid Preparation of a Plasma Membrane Fraction: Western Blot Detection of Translocated Glucose Transporter 4 from Plasma Membrane of Muscle and Adipose Cells and Tissues.Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4.Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes.Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is dependent upon both the amino terminus and the large cytoplasmic loop.A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling.A role of the C-terminus of aquaporin 4 in its membrane expression in cultured astrocytes.Identification of an insulin-responsive, slow endocytic recycling mechanism in Chinese hamster ovary cells.
P2860
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P2860
Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Exofacial epitope-tagged gluco ...... verning cellular localization.
@ast
Exofacial epitope-tagged gluco ...... verning cellular localization.
@en
type
label
Exofacial epitope-tagged gluco ...... verning cellular localization.
@ast
Exofacial epitope-tagged gluco ...... verning cellular localization.
@en
prefLabel
Exofacial epitope-tagged gluco ...... verning cellular localization.
@ast
Exofacial epitope-tagged gluco ...... verning cellular localization.
@en
P2093
P2860
P356
P1476
Exofacial epitope-tagged gluco ...... verning cellular localization.
@en
P2093
P2860
P304
P356
10.1083/JCB.123.1.127
P407
P577
1993-10-01T00:00:00Z