Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells.
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Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's DiseaseThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationNumerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic SynapsesAPP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cellsSoluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosisSecretases as therapeutic targets for the treatment of Alzheimer's disease.Advances with RNA interference in Alzheimer's disease research.Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture.Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons.Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo.Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema.Enhanced amyloidogenic processing of amyloid precursor protein and cell death under prolonged endoplasmic reticulum stress in brain endothelial cells.Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells.Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase.Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport.Abeta production as consequence of cellular death of a human neuroblastoma overexpressing APP.gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments.The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neuronsBeta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase.Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface.A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.β-Amyloid and the Pathomechanisms of Alzheimer's Disease: A Comprehensive View.A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site.Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42.Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease.Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors.The X11α Protein Slows Cellular Amyloid Precursor Protein Processing and Reduces Aβ40 and Aβ42 Secretion
P2860
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P2860
Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Novel beta-secretase cleavage ...... ate compartment of NT2N cells.
@ast
Novel beta-secretase cleavage ...... ate compartment of NT2N cells.
@en
type
label
Novel beta-secretase cleavage ...... ate compartment of NT2N cells.
@ast
Novel beta-secretase cleavage ...... ate compartment of NT2N cells.
@en
prefLabel
Novel beta-secretase cleavage ...... ate compartment of NT2N cells.
@ast
Novel beta-secretase cleavage ...... ate compartment of NT2N cells.
@en
P2093
P2860
P356
P1476
Novel beta-secretase cleavage ...... ate compartment of NT2N cells.
@en
P2093
P2860
P304
P356
10.1083/JCB.138.3.671
P407
P577
1997-08-01T00:00:00Z