The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum - Wikidata - wikimedia - TriplyDB

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum

http://www.wikidata.org/entity/Q36321326

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Mechanisms of CFTR Folding at the Endoplasmic Reticulum BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER Regulated release of ERdj3 from unfolded proteins by BiP Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells Polycystin-1: a master regulator of intersecting cystic pathways The Crystal Structure of the Human Co-Chaperone P58IPK Interaction of calmodulin with Sec61α limits Ca2+ leakage from the endoplasmic reticulum.Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.Cellular mechanisms of membrane protein folding.Evolutionary gain of function for the ER membrane protein Sec62 from yeast to humans BiP availability distinguishes states of homeostasis and stress in the endoplasmic reticulum of living cells.Live cell calcium imaging combined with siRNA mediated gene silencing identifies Ca²⁺ leak channels in the ER membrane and their regulatory mechanisms.J domain co-chaperone specificity defines the role of BiP during protein translocation Structure and function of the bacterial Sec translocon.Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats.Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades.Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy.Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability.Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.Polytopic membrane protein folding at L17 in the ribosome tunnel initiates cyclical changes at the translocon Transmembrane segments of nascent polytopic membrane proteins control cytosol/ER targeting during membrane integration The Candida albicans Kar2 protein is essential and functions during the translocation of proteins into the endoplasmic reticulum.Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon A Novel Method for Assessing the Chaperone Activity of Proteins.Versatility of the endoplasmic reticulum protein folding factory.Tyrosinase maturation through the mammalian secretory pathway: bringing color to life.BiP mutants that are unable to interact with endoplasmic reticulum DnaJ proteins provide insights into interdomain interactions in BiP.Pushing, pulling and trapping--modes of motor protein supported protein translocation.ERdj3 regulates BiP occupancy in living cells.Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.Life and death of a BiP substrate Organellar calcium buffers.Protein secretion and the endoplasmic reticulum.Combining polysaccharide biosynthesis and transport in a single enzyme: dual-function cell wall glycan synthases.Protein folding in the endoplasmic reticulum Signaling pathways from the endoplasmic reticulum and their roles in disease

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P2860

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum

http://www.wikidata.org/entity/Q36321326

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Arthur E Johnson

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Jeffrey L Brodsky

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Linda M Hendershot

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Nathan N Alder

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Ying Shen

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P2860

Mammalian Sec61 is associated with Sec62 and Sec63

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1

Structural analysis of substrate binding by the molecular chaperone DnaK

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane.

BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.

Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle

A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes

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