Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.
about
CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and DiseaseTherapeutic opportunities for targeting the ubiquitous cell surface receptor CD47CD47 regulates bone mass and tumor metastasis to boneRadioprotection in normal tissue and delayed tumor growth by blockade of CD47 signalingClinical lung xenotransplantation--what donor genetic modifications may be necessary?Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its managementPKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental SepsisCD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interestAmyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent mannerThe ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in plateletsThrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration.Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling.Immunobiology of liver xenotransplantation.Molecular regulation of tumor angiogenesis and perfusion via redox signaling.Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response.The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer.Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase.Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cellsThrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxationThrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP.Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient miceAge-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration.Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms.Effect and mechanism of thrombospondin-1 on the angiogenesis potential in human endothelial progenitor cells: an in vitro studyThe thrombospondins.Matricellular proteins in cardiac adaptation and disease.The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47.HMGB1: a novel protein that induced platelets active and aggregation via Toll-like receptor-4, NF-κB and cGMP dependent mechanisms.Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer.Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces.Therapeutic Targeting of CD47 to Modulate Tissue Responses to Ischemia and Radiation.CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model.Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury.Original insights on thrombospondin-1-related antireceptor strategies in cancer.Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model: implications for human disease.
P2860
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P2860
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Thrombospondin-1 stimulates pl ...... f nitric oxide/cGMP signaling.
@ast
Thrombospondin-1 stimulates pl ...... f nitric oxide/cGMP signaling.
@en
type
label
Thrombospondin-1 stimulates pl ...... f nitric oxide/cGMP signaling.
@ast
Thrombospondin-1 stimulates pl ...... f nitric oxide/cGMP signaling.
@en
prefLabel
Thrombospondin-1 stimulates pl ...... f nitric oxide/cGMP signaling.
@ast
Thrombospondin-1 stimulates pl ...... f nitric oxide/cGMP signaling.
@en
P2093
P2860
P1433
P1476
Thrombospondin-1 stimulates pl ...... f nitric oxide/cGMP signaling.
@en
P2093
Christine K Yu
Christine Yu
David A Wink
David D Roberts
Jeff S Isenberg
Jude Monsale
Khauh Nghiem
Margaret E Rick
Martin J Romeo
William A Frazier
P2860
P304
P356
10.1182/BLOOD-2007-06-098392
P407
P577
2007-09-21T00:00:00Z