ATM is required for efficient recombination between immunoglobulin switch regions. - Wikidata - wikimedia - TriplyDB

ATM is required for efficient recombination between immunoglobulin switch regions.

ATM is required for efficient recombination between immunoglobulin switch regions.

http://www.wikidata.org/entity/Q36399334

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ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events Ataxia-telangiectasia: future prospects IgH chain class switch recombination: mechanism and regulation ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks The histone methyltransferase MMSET regulates class switch recombination The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination Update on the hyper immunoglobulin M syndromes A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1 A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.Role of the translocation partner in protection against AID-dependent chromosomal translocations ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70 Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8 Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Chromatin remodeling, DNA damage repair and aging.The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain.ATM signalling and cancer.DNA double-strand break signaling and human disorders.Loss of ATM kinase activity leads to embryonic lethality in mice A precocious cerebellar ataxia and frequent Fever episodes in a 16-month-old infant revealing ataxia-telangiectasia syndrome.Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.Mechanism and regulation of class switch recombination Tying the loose ends together in DNA double strand break repair with 53BP1.Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.p53 represses class switch recombination to IgG2a through its antioxidant function

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P2860

ATM is required for efficient recombination between immunoglobulin switch regions.

http://www.wikidata.org/entity/Q36399334

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

ATM is required for efficient recombination between immunoglobulin switch regions.

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ATM is required for efficient recombination between immunoglobulin switch regions.

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type

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ATM is required for efficient recombination between immunoglobulin switch regions.

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ATM is required for efficient recombination between immunoglobulin switch regions.

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ATM is required for efficient recombination between immunoglobulin switch regions.

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ATM is required for efficient recombination between immunoglobulin switch regions.

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Journal of Experimental Medicine

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ATM is required for efficient recombination between immunoglobulin switch regions.

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P2093

André Nussenzweig

http://www.w3.org/2001/XMLSchema#string

Bernardo Reina-San-Martin

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Hua Tang Chen

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P2860

Transcription-coupled mutagenesis by the DNA deaminase AID

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

Internal IgH class switch region deletions are position-independent and enhanced by AID expression

Replication protein A-mediated recruitment and activation of Rad17 complexes

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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9

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200

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Michel C. Nussenzweig

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