Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells.
about
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activationPhospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for SykDifferential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesPhosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibodyDownstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptorSH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.Integrin VLA-5: modulator and activator of mast cells.One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors.Observing FcepsilonRI signaling from the inside of the mast cell membrane.Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells.Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.The mast cell: where endocytosis and regulated exocytosis meet.Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cellsClustered syk tyrosine kinase domains trigger phagocytosis.Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domainsActivation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells.Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor.Reconstitution of high affinity IgE receptor-mediated secretion by transfecting protein tyrosine kinase pp125FAK.Regulation of signalling through B-lymphocyte antigen receptors by cell-cell interaction molecules.Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase C gamma 2 in human platelets and phospholipase C gamma 1 in NIH-3T3 fibroblasts.In vitro and in vivo anti-allergic effects of Arctium lappa L.The yeast tribrid system--genetic detection of trans-phosphorylated ITAM-SH2-interactions.
P2860
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P2860
Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
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name
Clustering of Syk is sufficien ...... rat basophilic leukemia cells.
@ast
Clustering of Syk is sufficien ...... rat basophilic leukemia cells.
@en
type
label
Clustering of Syk is sufficien ...... rat basophilic leukemia cells.
@ast
Clustering of Syk is sufficien ...... rat basophilic leukemia cells.
@en
prefLabel
Clustering of Syk is sufficien ...... rat basophilic leukemia cells.
@ast
Clustering of Syk is sufficien ...... rat basophilic leukemia cells.
@en
P2860
P356
P1476
Clustering of Syk is sufficien ...... rat basophilic leukemia cells.
@en
P2093
J S Brugge
V M Rivera
P2860
P304
P356
10.1128/MCB.15.3.1582
P407
P577
1995-03-01T00:00:00Z