Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
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SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activitiesA phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genesCommon stemness regulators of embryonic and cancer stem cellsDNA demethylation and invasive cancer: implications for therapeuticsRGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activityGSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cellsMethylation mattersDnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencingDNA methylation, methyltransferases, and cancer.DNA methylation: past, present and future directions.High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene.DNA methyltransferases: a novel target for prevention and therapy.Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells.Epigenetic changes in the myelodysplastic syndrome.Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production.Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylationReduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.Transitions between epithelial and mesenchymal states during cell fate conversions.Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.DNA methylation, chromatin inheritance, and cancer.Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4'-thio-2'-deoxycytidine and 5-aza-4'-thio-2'-deoxycytidine.Methylation and colorectal cancer.Alteration of DNA methylation in gastrointestinal carcinogenesis.Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation.DNA methylation, imprinting and cancer.Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver.6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1DNA methylation and gene silencing in cancer: which is the guilty party?DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activationAUF1 cell cycle variations define genomic DNA methylation by regulation of DNMT1 mRNA stabilityRetinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complexToxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.Viral oncoproteins target the DNA methyltransferases.Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.Epigenetic reprogramming as a key contributor to melanocyte malignant transformation.Procainamide is a specific inhibitor of DNA methyltransferase 1.RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylationHypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein
P2860
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P2860
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Expression of an exogenous euk ...... ansformation of NIH 3T3 cells.
@ast
Expression of an exogenous euk ...... ansformation of NIH 3T3 cells.
@en
type
label
Expression of an exogenous euk ...... ansformation of NIH 3T3 cells.
@ast
Expression of an exogenous euk ...... ansformation of NIH 3T3 cells.
@en
prefLabel
Expression of an exogenous euk ...... ansformation of NIH 3T3 cells.
@ast
Expression of an exogenous euk ...... ansformation of NIH 3T3 cells.
@en
P2093
P2860
P356
P1476
Expression of an exogenous euk ...... ransformation of NIH 3T3 cells
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.19.8891
P407
P577
1993-10-01T00:00:00Z