Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.
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Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptorA reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor αStimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteinsThe platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputsA role for Src in signal relay by the platelet-derived growth factor alpha receptorSequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor speciesA Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST.The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas.A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transductionThe tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V.Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species.NF-kappaB controls growth of glioblastomas/astrocytomas.Recruitment of the protein-tyrosine phosphatase SHP-2 to the C-terminal tyrosine of the prolactin receptor and to the adaptor protein Gab2.Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis.Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activationThe oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart.Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity.Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance.Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway.The autophosphorylated Ser686, Thr688, and Ser689 residues in the intracellular juxtamembrane domain of XA21 are implicated in stability control of rice receptor-like kinase.Hepatic stellate cell-derived PDGFRα-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.
P2860
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P2860
Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Phosphorylation of tyrosine 72 ...... of Ras or cell proliferation.
@ast
Phosphorylation of tyrosine 72 ...... of Ras or cell proliferation.
@en
type
label
Phosphorylation of tyrosine 72 ...... of Ras or cell proliferation.
@ast
Phosphorylation of tyrosine 72 ...... of Ras or cell proliferation.
@en
prefLabel
Phosphorylation of tyrosine 72 ...... of Ras or cell proliferation.
@ast
Phosphorylation of tyrosine 72 ...... of Ras or cell proliferation.
@en
P2093
P2860
P921
P356
P1476
Phosphorylation of tyrosine 72 ...... of Ras or cell proliferation.
@en
P2093
A Kazlauskas
C E Bazenet
J A Gelderloos
P2860
P304
P356
10.1128/MCB.16.12.6926
P407
P577
1996-12-01T00:00:00Z