about
In the light of directed evolution: pathways of adaptive protein evolutionProtein stability promotes evolvabilityExploring protein fitness landscapes by directed evolutionProtein stability: computation, sequence statistics, and new experimental methodsEngineering protocells: prospects for self-assembly and nanoscale production-linesA structural view of evolutionary divergenceStructural Bases for Stability–Function Tradeoffs in Antibiotic ResistanceEngineering protein thermostability using a generic activity-independent biophysical screen inside the cellStructural insights into N-terminal to C-terminal interactions and implications for thermostability of a (β/α)8-triosephosphate isomerase barrel enzymeDirected evolution converts subtilisin E into a functional equivalent of thermitaseHyperthermophilic enzymes: sources, uses, and molecular mechanisms for thermostabilityThermodynamics of neutral protein evolutionRetrovolution: HIV-driven evolution of cellular genes and improvement of anticancer drug activationRole of the amino latch of staphylococcal alpha-hemolysin in pore formation: a co-operative interaction between the N terminus and position 217.Increased thermostability of microbial transglutaminase by combination of several hot spots evolved by random and saturation mutagenesis.Thermostability of in vitro evolved Bacillus subtilis lipase A: a network and dynamics perspective.Directed evolution of a histone acetyltransferase--enhancing thermostability, whilst maintaining catalytic activity and substrate specificity.Engineering of Bacillus lipase by directed evolution for enhanced thermal stability: effect of isoleucine to threonine mutation at protein surface.Self-replicating colloidal clustersComputational method to reduce the search space for directed protein evolution.A novel, high performance enzyme for starch liquefaction. Discovery and optimization of a low pH, thermostable alpha-amylase.Investigating and Engineering Enzymes by Genetic Selection.DNA family shuffling of hyperthermostable beta-glycosidases.Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies.Simultaneous enhancement of thermostability and catalytic activity of phospholipase A(1) by evolutionary molecular engineering.Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris.High efficiency family shuffling based on multi-step PCR and in vivo DNA recombination in yeast: statistical and functional analysis of a combinatorial library between human cytochrome P450 1A1 and 1A2Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks.eCodonOpt: a systematic computational framework for optimizing codon usage in directed evolution experimentsCharacterisation of a New Family of Carboxyl Esterases with an OsmC DomainImproving the carboligase activity of benzoylformate decarboxylase from Pseudomonas putida by a combination of directed evolution and site-directed mutagenesis.Laboratory-directed protein evolutionHeterologous overexpression of a mutant termite cellulase gene in Escherichia coli by DNA shuffling of four orthologous parental cDNAs.How protein stability and new functions trade offInferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin.Evolving thermostability in mutant libraries of ligninolytic oxidoreductases expressed in yeast.Hyperthermophilic phosphotriesterases/lactonases for the environment and human health.Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei modelDynamically-driven enhancement of the catalytic machinery of the SARS 3C-like protease by the S284-T285-I286/A mutations on the extra domain.Enhanced refoldability and thermoactivity of fluorinated phosphotriesterase.
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Directed evolution of a thermostable esterase.
@ast
Directed evolution of a thermostable esterase.
@en
type
label
Directed evolution of a thermostable esterase.
@ast
Directed evolution of a thermostable esterase.
@en
prefLabel
Directed evolution of a thermostable esterase.
@ast
Directed evolution of a thermostable esterase.
@en
P2093
P2860
P356
P1476
Directed evolution of a thermostable esterase
@en
P2093
F H Arnold
P O Freskgard
P2860
P304
12809-12813
P356
10.1073/PNAS.95.22.12809
P407
P577
1998-10-01T00:00:00Z