Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency
about
Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection.Identification of the pseudorabies virus promoter required for latency-associated transcript gene expression in the natural host.Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latencyThe 2.2-kilobase latency-associated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic miceLAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans.The stable 2.0-kilobase intron of the herpes simplex virus type 1 latency-associated transcript does not function as an antisense repressor of ICP0 in nonneuronal cellsExperimental investigation of herpes simplex virus latencyA 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpesThe characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript regionTransgenic mouse with the herpes simplex virus type 1 latency-associated gene: expression and function of the transgeneAlternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells.Latency-associated transcript (LAT) exon 1 controls herpes simplex virus species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of LATHerpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell lineA protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSVHerpes Simplex Virus 2 Latency-Associated Transcript (LAT) region mutations do not identify a role for LAT-Associated Micro RNAs in viral reactivation in the Guinea Pig Genital Model.
P2860
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P2860
Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Two open reading frames (ORF1 ...... for reactivation from latency
@ast
Two open reading frames (ORF1 ...... for reactivation from latency
@en
type
label
Two open reading frames (ORF1 ...... for reactivation from latency
@ast
Two open reading frames (ORF1 ...... for reactivation from latency
@en
prefLabel
Two open reading frames (ORF1 ...... for reactivation from latency
@ast
Two open reading frames (ORF1 ...... for reactivation from latency
@en
P2860
P1433
P1476
Two open reading frames (ORF1 ...... for reactivation from latency
@en
P2093
J G Spivack
M U Fareed
P2860
P304
P407
P577
1994-12-01T00:00:00Z