Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
about
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingTelomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumorsTelomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaksInvolvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindleEarly embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during developmentDistinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutantsFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionTargeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsG2E3 is a dual function ubiquitin ligase required for early embryonic developmentGeneration of bovine transgenics using somatic cell nuclear transferCreation of non-human primate neurogenetic disease models by gene targeting and nuclear transferTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyModeling the study of DNA damage responses in miceA peek into the complex realm of histone phosphorylationRecovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.Ataxia telangiectasia: a reviewTargeted disruption of NBS1 reveals its roles in mouse development and DNA repair.Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cellsRegulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cellsLoss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesisThe mouse homolog of Drosophila Vasa is required for the development of male germ cellsc-Abl is required for development and optimal cell proliferation in the context of p53 deficiencyIdentification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouseChemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased CarcinogenesisHeterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient miceTumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutationCaspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene functionGenomic instability in mice lacking histone H2AXAccumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient miceThe Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineageThe role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotectionInvestigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.Cancer risk and the ATM gene: a continuing debate.Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice.Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activationIndependent recruitment of Igh alleles in V(D)J recombination.
P2860
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P2860
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
@ast
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
@en
type
label
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
@ast
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
@en
prefLabel
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
@ast
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
@en
P2093
P2860
P356
P1476
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
@en
P2093
C C Morton
C J Daugherty
J Campos-Torres
P2860
P304
13084-13089
P356
10.1073/PNAS.93.23.13084
P407
P577
1996-11-01T00:00:00Z