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Diverse metastable structures formed by small oligomers of α-synuclein probed by force spectroscopyStructures of the E46K mutant-type α-synuclein protein and impact of E46K mutation on the structures of the wild-type α-synuclein proteinPre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease modelsThe N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranesVersatile Structures of α-SynucleinFish Synucleins: An UpdateMechanisms of amyloid formation revealed by solution NMRGlia and alpha-synuclein in neurodegeneration: A complex interactionDynamic -Helix Structure of Micelle-bound Human AmylinNMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP 248−286Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formationStructure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environmentAmyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicityOut-of-register -sheets suggest a pathway to toxic amyloid aggregatesSequestration of a β-hairpin for control of α-synuclein aggregationCuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and CytotoxicityDistinct α-synuclein strains differentially promote tau inclusions in neuronsMechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescenceThe Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implicationCryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibrilPhosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactionsα-Synuclein oligomers impair neuronal microtubule-kinesin interplay.Early aggregation steps in alpha-synuclein as measured by FCS and FRET: evidence for a contagious conformational change.α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotectionDifferential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopyThe clustering and spatial arrangement of beta-sheet sequence, but not order, govern alpha-synuclein fibrillogenesisEvidence for copper-dioxygen reactivity during alpha-synuclein fibril formation.Direct observation of the interconversion of normal and toxic forms of α-synucleinIdentification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregationCovalent α-synuclein dimers: chemico-physical and aggregation properties.Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregationBinding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.Amide proton solvent protection in amylin fibrils probed by quenched hydrogen exchange NMR.Towards revealing the structure of bacterial inclusion bodies.Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide.In vivo demonstration that alpha-synuclein oligomers are toxic.Labeling proteins with fluorophore/thioamide Förster resonant energy transfer pairs by combining unnatural amino acid mutagenesis and native chemical ligationResidue-specific fluorescent probes of α-synuclein: detection of early events at the N- and C-termini during fibril assemblyStructural insights into functional and pathological amyloid.The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The fold of alpha-synuclein fibrils.
@ast
The fold of alpha-synuclein fibrils.
@en
type
label
The fold of alpha-synuclein fibrils.
@ast
The fold of alpha-synuclein fibrils.
@en
prefLabel
The fold of alpha-synuclein fibrils.
@ast
The fold of alpha-synuclein fibrils.
@en
P2093
P2860
P50
P356
P1476
The fold of alpha-synuclein fibrils.
@en
P2093
Dominique Riek-Loher
Hui-Ting Chou
Roland Riek
Thorsten Lührs
P2860
P304
P356
10.1073/PNAS.0712179105
P407
P577
2008-06-12T00:00:00Z