In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen - Wikidata - wikimedia - TriplyDB

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

http://www.wikidata.org/entity/Q36736936

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High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase Spiroindolones, a potent compound class for the treatment of malaria Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs Next-generation antimicrobials: from chemical biology to first-in-class drugs Global phenotypic screening for antimalarials Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles Recent advances in malaria drug discovery Using genetic methods to define the targets of compounds with antimalarial activity Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model Design and Synthesis of Inhibitors of Plasmodium falciparumN -Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery Antimalarial drug discovery - approaches and progress towards new medicines.Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery Targeting Plasmodium PI(4)K to eliminate malaria In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery Muddled mechanisms: recent progress towards antimalarial target identification ChEMBL: a large-scale bioactivity database for drug discovery Phenotypic screens, chemical genomics, and antimalarial lead discovery Integrated dataset of screening hits against multiple neglected disease pathogens P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action A chemocentric approach to the identification of cancer targets Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families A new in vivo screening paradigm to accelerate antimalarial drug discovery Prediction of the P. falciparum target space relevant to malaria drug discovery Exploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteria Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products Hemozoin and antimalarial drug discovery High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens Chemical genetics of Plasmodium falciparum The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens Natural products as starting points for future anti-malarial therapies: going back to our roots?

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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

http://www.wikidata.org/entity/Q36736936

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In silico activity profiling r ...... ed in a high-throughput screen

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Proceedings of the National Academy of Sciences of the United States of America

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Achim Brinker

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Advait Nagle

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Arnab Chatterjee

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Case McNamara

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David Plouffe

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Francisco Adrián

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Jason T Matzen

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Jeff Janes

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Jeremy S Caldwell

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Kelli Kuhen

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P2860

Insights into antifolate resistance from malarial DHFR-TS structures

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Evidence-based annotation of the malaria parasite's genome using comparative expression profiling

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

Fulfilling the promise: drug discovery in the post-genomic era.

Novel statistical approach for primary high-throughput screening hit selection.

A clinical drug library screen identifies astemizole as an antimalarial agent.

Searching for new antimalarial therapeutics amongst known drugs.

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Elizabeth Winzeler

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