Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. - Wikidata - wikimedia - TriplyDB

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

http://www.wikidata.org/entity/Q36800426

about

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia Direct inhibition of the NOTCH transcription factor complex Targeting Notch to overcome radiation resistance Oncogenic Kras initiates leukemia in hematopoietic stem cells Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade Murine models of acute leukemia: important tools in current pediatric leukemia research.Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model.Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.Constitutive MAP kinase activation in hematopoietic stem cells induces a myeloproliferative disorder.Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice Notch target gene deregulation and maintenance of the leukemogenic phenotype do not require RBP-J kappa in Ikaros null mice.Notch dimerization is required for leukemogenesis and T-cell development.A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1.Cyclin C is a haploinsufficient tumour suppressor.Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Role of Notch and its oncogenic signaling crosstalk in breast cancer.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells.Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model.Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling.High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think.Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

P2860

Q24296476-7A676F30-E4BA-4B18-96AC-5C48AF64C383 Q24307557-F0A7E0FA-FF3E-4525-9453-570596C1FF84 Q24310753-DE12CC74-2F1E-4AD0-BB22-157900301CA9 Q24634015-4311AFA9-880F-429E-AC71-7834AE914F27 Q26771701-90CA1BAA-CFD9-461B-BAFE-1988BC66D290 Q27331698-634A4008-5AD7-4E53-A571-F78E992797C8 Q27704829-B2229397-D8FA-4781-ABA2-F57794B0A03F Q28115221-5F67DBEB-078D-4305-8562-A9D435204728 Q30493785-A6D93458-3429-46BF-898B-7B6E5D2DFB7F Q33494549-AFCFEF9B-E818-4B15-9F11-907EB2DA80FA Q33559587-A47783E5-6565-4ED8-9788-72D8DFBF20A6 Q33606018-94911CC9-9C23-43D1-968C-312A53F7F1C9 Q33677433-B37FDC9F-4AB7-4EFE-9826-2AE0A9A121D9 Q33734728-170A9244-7BAF-49F1-AAC4-E14B4B3D1CAF Q33739961-0F598C16-6212-40C6-9DC4-62EE688146D0 Q33822130-B7340FA1-647C-44A0-B32D-9CC218665006 Q34055685-88FCDBE5-F4A9-47A5-B685-3826FC5E9FA8 Q34099193-7426C8BB-A690-422E-80D7-BFD2DE36FD54 Q34151863-8C1BC352-D426-473F-9DF0-CF64850CECCB Q34186057-3D692C9B-0D8B-46B0-9EAD-0634CD0F26EA Q34204349-330D19A3-8D2C-4D33-9E64-26D9A368F864 Q34244256-8E5CDB43-F75E-4DDA-8503-910B6F939523 Q34315750-59193548-08E7-46CE-A90A-8AF97B18EF0F Q34376282-1FAC2BAD-B238-4B26-B636-05FC2D88B4FF Q34390573-FFA5147A-C7A6-47C1-A481-D6A7E31D88CE Q34444847-12894582-1BFA-4B77-AE8F-8E71CC135236 Q34446281-A3F7826F-0504-43A2-A0DF-211DE4BFC8BE Q34450702-5D4CBAC3-73F3-4F63-BF93-0D8771F880C9 Q34541666-27C25017-C1F0-4DC5-B1AC-DACE2EC97915 Q34697373-F7D73A70-5728-4628-B411-454D4F20C6F0 Q34732289-5DC9798D-6172-43D1-82C8-603279C8C63C Q34999834-C3DF65D8-7A45-47E8-89EA-7364A0471281 Q35029964-8863E62E-54DD-4366-9187-F190196A3083 Q35083157-87DA92EC-BE6E-428F-9199-A7EA5C4AFD20 Q35083254-C5B32C90-A211-48E3-852E-D93048F489DF Q35085362-70E40A10-B8E2-4C2F-98D1-E2E4C7027D4D Q35128030-59645E6D-3155-4360-8471-545C17290C37 Q35208383-57E50967-19FA-4DA0-8D75-EA46DD5C09B9 Q35237466-A723B2A6-59B8-4BE2-9B62-4573F61C94DB Q35471421-7DE37669-FA34-4D8E-9B1B-3CE72862EA15

P2860

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

http://www.wikidata.org/entity/Q36800426

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Leukemia-associated NOTCH1 all ...... rate K-ras-initiated leukemia.

@ast

Leukemia-associated NOTCH1 all ...... rate K-ras-initiated leukemia.

@en

type

label

Leukemia-associated NOTCH1 all ...... rate K-ras-initiated leukemia.

@ast

Leukemia-associated NOTCH1 all ...... rate K-ras-initiated leukemia.

@en

prefLabel

Leukemia-associated NOTCH1 all ...... rate K-ras-initiated leukemia.

@ast

Leukemia-associated NOTCH1 all ...... rate K-ras-initiated leukemia.

@en

P1433

Q36800426-D598B4B4-14D3-4107-A88B-336F35A24721

P1476

Q36800426-48259DBB-248D-4E25-BECD-A806F1E810F1

P2093

Q36800426-50997700-7E38-40C6-8B0B-99AF041E84FD

Q36800426-547661FD-735D-4BAB-A983-53D3296469D3

Q36800426-690B6254-5648-410D-91C5-90A7715981C1

Q36800426-844AEAB9-99BB-4502-9982-71A60FA7C748

Q36800426-88812732-3C2B-4965-B134-639DC34453B9

Q36800426-9BC210EF-AD19-40B4-82AB-962A35F466FB

Q36800426-B77B2C68-1902-4E1D-999D-18B60D7DCB64

Q36800426-BD99B229-58CB-4F6A-88D1-D7C17453C299

Q36800426-C6EE0BAF-BC66-4093-822B-96C1650DC741

Q36800426-EDBC7EA6-DFB2-4C86-BC3C-00EB6A520892

P2860

Q36800426-02CF13A2-E834-41EA-956D-1DF964043317

Q36800426-0AEE89C8-BE1E-4B2E-AA63-22ADF4F94272

Q36800426-0B035786-25A8-444C-BEB6-64FC7CC968C2

Q36800426-0CB84BE0-0856-4419-831D-331DEBBE5705

Q36800426-0D640C44-B057-45D5-B621-3A1C3B9788FC

Q36800426-0DB2308E-2DA9-47DA-B36B-B8DF49998405

Q36800426-0DC7D5D5-C2BE-4B24-B245-824074CE342F

Q36800426-1125E730-0D08-4301-87B5-57FC4DFCACDC

Q36800426-13C6F19B-024F-411A-9088-3768CD14C412

Q36800426-1ED87865-6BE2-4B11-B732-B1ABDB12C4D9

P304

Q36800426-8DB507D4-D14B-44E6-98BA-1AD88B9F9A20

P31

Q36800426-A55CCA9C-99FB-4DDB-9867-3A37EE720CE8

P356

Q36800426-4BD8EE7C-B757-4D61-91FD-A3727CD7E10B

P407

Q36800426-7CA11F0D-6059-4179-B9F7-79711900E344

P433

Q36800426-F3DDCA9A-5EA5-41B8-ADCA-E497C1411323

P478

Q36800426-B192FDFD-CD0B-432F-8646-D1BB69AEC448

P577

Q36800426-4115A863-AE20-4556-B68A-4E54985373C1

P698

Q36800426-2EF730D1-11CB-4E73-9513-D7B7C6A26220

P921

Q36800426-C27C4C35-D8A7-44F0-8200-2CA070016177

P932

Q36800426-874730D4-A9DF-48FF-87F8-B2212D7A5D9C

P356

P1433

Journal of Clinical Investigation

P1476

Leukemia-associated NOTCH1 all ...... rate K-ras-initiated leukemia.

@en

P2093

Candice Romany

http://www.w3.org/2001/XMLSchema#string

Gavin Histen

http://www.w3.org/2001/XMLSchema#string

Jon C Aster

http://www.w3.org/2001/XMLSchema#string

Lanwei Xu

http://www.w3.org/2001/XMLSchema#string

M Eden Childs

http://www.w3.org/2001/XMLSchema#string

Mark Y Chiang

http://www.w3.org/2001/XMLSchema#string

Olga Shestova

http://www.w3.org/2001/XMLSchema#string

Phyllis A Gimotty

http://www.w3.org/2001/XMLSchema#string

Sarah L'heureux

http://www.w3.org/2001/XMLSchema#string

Warren S Pear

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

The Notch1 receptor is cleaved constitutively by a furin-like convertase

Structural basis for autoinhibition of Notch

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

P304

3181-3194

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI35090

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

118

http://www.w3.org/2001/XMLSchema#string

P577

2008-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18677410

http://www.w3.org/2001/XMLSchema#string

P921

P932

2491459

http://www.w3.org/2001/XMLSchema#string