Mechanism of DNase I hypersensitive site formation within the human globin locus control region.
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A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteinsGenetic regulation of delta-aminolevulinate dehydratase during erythropoiesisEffect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor bindingSequences downstream of the erythroid promoter are required for high level expression of the human alpha-spectrin gene.The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosisRegulation of the globin genes.An Erythroid-Specific Chromatin Opening Element Increases β-Globin Gene Expression from Integrated Retroviral Gene Transfer Vectors.Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.Effective automated feature construction and selection for classification of biological sequences.Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression.Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sitesA dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.Analysis of erythroid nuclear proteins binding to the promoter and enhancer elements of the chicken histone H5 geneRegulation of Drosophila yolk protein genes by an ovary-specific GATA factorEssential role of NF-E2 in remodeling of chromatin structure and transcriptional activation of the epsilon-globin gene in vivo by 5' hypersensitive site 2 of the beta-globin locus control regionTranscriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter.Fast-muscle-specific expression of human aldolase A transgenesAn enhancer/locus control region is not sufficient to open chromatin.Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell linesRegulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vectorDiscovery of functional noncoding elements by digital analysis of chromatin structure.Globin gene switching. In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.Slow and Steady Wins The Race? Progress in the Development of Vectors for Gene Therapy of β-Thalassemia and Sickle Cell Disease.Sequences within and flanking hypersensitive sites 3 and 2 of the beta-globin locus control region required for synergistic versus additive interaction with the epsilon-globin gene promoter.Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer.Intergenic transcription and transinduction of the human beta-globin locus.Chromosomal position effects in chicken lysozyme gene transgenic mice are correlated with suppression of DNase I hypersensitive site formation.The mouse beta-globin locus control region: hypersensitive sites 3 and 4.NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human beta-globin locus control region.Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the beta-globin locus control region. Domain opening and synergism between HS2 and HS3.Distinction between AP1 and NF-E2 factor-binding at specific chromatin regions in mammalian cells.Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation.Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.In vivo formation of a human beta-globin locus control region core element requires binding sites for multiple factors including GATA-1, NF-E2, erythroid Kruppel-like factor, and Sp1.A two-stage evolutionary approach for effective classification of hypersensitive DNA sequences.Apolipoprotein B gene expression in a series of human apolipoprotein B transgenic mice generated with recA-assisted restriction endonuclease cleavage-modified bacterial artificial chromosomes. An intestine-specific enhancer element is located betweeHuman apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine.
P2860
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P2860
Mechanism of DNase I hypersensitive site formation within the human globin locus control region.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Mechanism of DNase I hypersens ...... n globin locus control region.
@en
type
label
Mechanism of DNase I hypersens ...... n globin locus control region.
@en
prefLabel
Mechanism of DNase I hypersens ...... n globin locus control region.
@en
P2093
P2860
P356
P1476
Mechanism of DNase I hypersens ...... n globin locus control region.
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.3.1143
P407
P577
1992-02-01T00:00:00Z