The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells.
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The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutationsA region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasisInteraction between the HPV E7 oncoprotein and the transcriptional coactivator p300Induction of AP-1 DNA-binding activity and c-fos mRNA by the adenovirus 243R E1A protein and cyclic AMP requires domains necessary for transformation.Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.Role of p300-family proteins in E1A oncogene induction of cytolytic susceptibility and tumor cell rejectionThe adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cellsRepression of liver-specific hepatitis B virus enhancer 2 activity by adenovirus E1A proteins.Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene productsAdenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domainsE1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products.The degradation sequence of adenovirus E1A consists of the amino-terminal tetrapeptide Met-Arg-His-Ile.Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activityExpression and interactions of human adenovirus oncoproteins.Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.The human papillomavirus type 16 E7 protein complements adenovirus type 5 E1A amino-terminus-dependent transactivation of adenovirus type 5 early genes and increases ATF and Oct-1 DNA binding activity.In vitro analysis of the E1A-homologous sequences of RIZ.Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanismsComplementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells.Maintenance of cellular proliferation by adenovirus early region 1A in fibroblasts conditionally immortalized by using simian virus 40 large T antigen requires conserved region 1.Interaction of a common factor with ATF, Sp1, or TATAA promoter elements is required for these sequences to mediate transactivation by the adenoviral oncogene E1aIdentification and analysis of a retinoblastoma binding motif in the replication protein of a plant DNA virus: requirement for efficient viral DNA replication.CBP-induced stimulation of c-Fos activity is abrogated by E1A.The adenovirus E1A protein overrides the requirement for cellular ras in initiating DNA synthesis.Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism.
P2860
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P2860
The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
The amino-terminal region of t ...... primary baby rat kidney cells.
@en
type
label
The amino-terminal region of t ...... primary baby rat kidney cells.
@en
prefLabel
The amino-terminal region of t ...... primary baby rat kidney cells.
@en
P2860
P356
P1476
The amino-terminal region of t ...... primary baby rat kidney cells.
@en
P2093
P2860
P304
P356
10.1128/MCB.8.9.3882
P407
P577
1988-09-01T00:00:00Z