Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
about
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesOncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switchingATM damage response and XLF repair factor are functionally redundant in joining DNA breaksToll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responsesImpaired B cell development and function in the absence of IkappaBNSDNA demethylation dynamicsRobust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationPrimary immunoglobulin repertoire development: time and space matterAID targeting is dependent on RNA polymerase II pausing.IgH class switching and translocations use a robust non-classical end-joining pathwayThe splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNAThe histone methyltransferase MMSET regulates class switch recombinationAppraisal of microbial evolution to commensalism and pathogenicity in humansIntegrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceEvolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.Patterns of receptor revision in the immunoglobulin heavy chains of a teleost fishDifferential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombinationAlternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.Roles of the NF-kappaB pathway in lymphocyte development and function.Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.Origin of chromosomal translocations in lymphoid cancer.Mechanisms promoting translocations in editing and switching peripheral B cells.High resolution analysis of the chromatin landscape of the IgE switch region in human B cellsG-quadruplex nucleic acids and human diseaseWidespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.AID-initiated DNA lesions are differentially processed in distinct B cell populations.
P2860
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P2860
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
@en
type
label
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
@en
prefLabel
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
@en
P2093
P1476
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
@en
P2093
Abhishek Datta
Ali Zarrin
Catherine Yan
Frederick W Alt
Jayanta Chaudhuri
John Manis
Ryan T Phan
Sonia Franco
P304
P356
10.1016/S0065-2776(06)94006-1
P577
2007-01-01T00:00:00Z