Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable
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Primary erythromelalgia: a reviewComparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and LidocaineRelationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in ratsStructure-based assessment of disease-related mutations in human voltage-gated sodium channels.Alternative splicing of Na(V)1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T.Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disordersSynthesis and analgesic effects of μ-TRTX-Hhn1b on models of inflammatory and neuropathic pain.Ion channelopathies in functional GI disorders.Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations.Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin.Navβ4 regulates fast resurgent sodium currents and excitability in sensory neuronsPharmacogenetics of analgesic drugsThe AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.Network topology of NaV1.7 mutations in sodium channel-related painful disorders.Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgiaMicroRNA-30b regulates expression of the sodium channel Nav1.7 in nerve injury-induced neuropathic pain in the ratThermosensory and mechanosensory perception in human genetic disease.Pain disorders and erythromelalgia caused by voltage-gated sodium channel mutations.Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes.Neurological perspectives on voltage-gated sodium channels.Mutational consequences of aberrant ion channels in neurological disorders.Translational pain research: Lessons from genetics and genomics.What are the treatment options for paroxysmal extreme pain disorder?Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.Molecular architecture of a sodium channel S6 helix: radial tuning of the voltage-gated sodium channel 1.7 activation gateExtending the clinical spectrum of pain channelopathies.Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels.Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn.NaV1.7: stress-induced changes in immunoreactivity within magnocellular neurosecretory neurons of the supraoptic nucleus.Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons.Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation.Nonlinear effects of hyperpolarizing shifts in activation of mutant Nav1.7 channels on resting membrane potential.Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation.Channelopathy: a novel mutation in the SCN9A gene causes insensitivity to pain and autonomic dysregulation.Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation.Flushing Disorders Associated with Gastrointestinal Symptoms: Part 2, Systemic Miscellaneous Conditions.Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802.
P2860
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P2860
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Paroxysmal extreme pain disord ...... ers DRG neurons hyperexcitable
@en
type
label
Paroxysmal extreme pain disord ...... ers DRG neurons hyperexcitable
@en
prefLabel
Paroxysmal extreme pain disord ...... ers DRG neurons hyperexcitable
@en
P2093
P2860
P356
P1433
P1476
Paroxysmal extreme pain disord ...... ers DRG neurons hyperexcitable
@en
P2093
Brian W Jarecki
Lynda Tyrrell
Mark Lawden
Stephen G Waxman
Sulayman D Dib-Hajj
Tanya Z Fischer
Theodore R Cummins
P2860
P2888
P356
10.1186/1744-8069-4-37
P50
P577
2008-09-19T00:00:00Z
P5875
P6179
1001637090