Ikaros represses the transcriptional response to Notch signaling in T-cell development.
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Role of Ikaros in T-cell acute lymphoblastic leukemiaStructural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexesTLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.Notch target gene deregulation and maintenance of the leukemogenic phenotype do not require RBP-J kappa in Ikaros null mice.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development.The evolution of thymic lymphomas in p53 knockout miceAlternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.Vasoactive intestinal peptide signaling axis in human leukemia.Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease.Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.Irreversibility of T-Cell Specification: Insights from Computational Modelling of a Minimal Network Architecture.Biochemical and cellular characterization of transcription factors binding to the hyperconserved core promoter-associated M4 motif.Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.Master regulators of infiltrate recruitment in autoimmune disease identified through network-based molecular deconvolution.Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemiaIkaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signalingActivated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.Ikaros Is a Negative Regulator of B1 Cell Development and Function.Ikaros controls isotype selection during immunoglobulin class switch recombination.Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia.In vivo mapping of notch pathway activity in normal and stress hematopoiesis.Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells.Eliciting the T cell fate with Notch.Ikaros in immune receptor signaling, lymphocyte differentiation, and function.Ikaros and tumor suppression in acute lymphoblastic leukemiaDevelopmental gene networks: a triathlon on the course to T cell identity.Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control.Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T cell growth.The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma.Cytokines, Transcription Factors, and the Initiation of T-Cell Development.A transcriptionally permissive epigenetic landscape at the vasoactive intestinal peptide receptor-1 promoter suggests a euchromatin nuclear position in murine CD4 T cells.Ikaros in B cell development and function.TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes.Ikaros is a critical target during simultaneous exposure to X-rays and N-ethyl-N-nitrosourea in mouse T-cell lymphomagenesis.
P2860
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P2860
Ikaros represses the transcriptional response to Notch signaling in T-cell development.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Ikaros represses the transcriptional response to Notch signaling in T-cell development.
@en
type
label
Ikaros represses the transcriptional response to Notch signaling in T-cell development.
@en
prefLabel
Ikaros represses the transcriptional response to Notch signaling in T-cell development.
@en
P2093
P2860
P356
P1476
Ikaros represses the transcriptional response to Notch signaling in T-cell development.
@en
P2093
Anne-Solen Geimer Le Lay
Eva Kleinmann
MacLean Sellars
Philippe Kastner
Susan Chan
P2860
P304
P356
10.1128/MCB.00715-08
P407
P577
2008-10-13T00:00:00Z