A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.
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20-HETE and blood pressure regulation: clinical implicationsProtective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncouplingA synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in ratsEffects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock.Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potentialContribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats.Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shockNS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite.20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic Target20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertensionContribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.Bexarotene, a Selective RXRα Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock.
P2860
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P2860
A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on September 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A 20-hydroxyeicosatetraenoic a ...... ity in endotoxin-treated rats.
@en
A 20-hydroxyeicosatetraenoic a ...... ity in endotoxin-treated rats.
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type
label
A 20-hydroxyeicosatetraenoic a ...... ity in endotoxin-treated rats.
@en
A 20-hydroxyeicosatetraenoic a ...... ity in endotoxin-treated rats.
@nl
prefLabel
A 20-hydroxyeicosatetraenoic a ...... ity in endotoxin-treated rats.
@en
A 20-hydroxyeicosatetraenoic a ...... ity in endotoxin-treated rats.
@nl
P2093
P2860
P1433
P1476
A 20-hydroxyeicosatetraenoic a ...... vity in endotoxin-treated rats
@en
P2093
Belma Korkmaz
C Kemal Buharalioglu
Kafait U Malik
Richard J Roman
Seyhan Sahan Firat
Siddam Anjaiah
P2860
P304
P356
10.1097/SHK.0B013E31816471C6
P577
2008-09-01T00:00:00Z