Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.
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Targeting xenobiotic receptors PXR and CAR for metabolic diseasesTargeting xenobiotic receptors PXR and CAR in human diseasesMechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalateA single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Bioassay-directed fractionation for discovery of bioactive neutral lipids guided by relative mass defect filtering and multiplexed collision-induced dissociation.Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.Activation of xenobiotic receptors: driving into the nucleus.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesSelective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptorDifferential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirineMulti-species analyses of direct activators of the constitutive androstane receptor.Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in miceSmall-molecule modulators of the constitutive androstane receptor.Small-molecule modulators of PXR and CAR.Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in LiverThe orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.Expression of human CAR splicing variants in BAC-transgenic miceNonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes.Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analoguesOxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy.Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.Regulation of gene expression by CAR: an update.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Nuclear receptors and nonalcoholic fatty liver disease.Activation of the Constitutive Androstane Receptor by MonophthalatesFunctional role of phospholipase D (PLD) in di(2-ethylhexyl) phthalate-induced hepatotoxicity in Sprague-Dawley rats.Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression.
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Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 11 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Di(2-ethylhexyl) phthalate is ...... receptor splice variant CAR2.
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type
label
Di(2-ethylhexyl) phthalate is ...... receptor splice variant CAR2.
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prefLabel
Di(2-ethylhexyl) phthalate is ...... receptor splice variant CAR2.
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P2093
P2860
P356
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Di(2-ethylhexyl) phthalate is ...... e receptor splice variant CAR2
@en
P2093
Curtis J Omiecinski
Joshua G DeKeyser
K Sandeep Prabhu
Michael C Stagliano
Scott S Auerbach
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P304
P356
10.1124/MOL.108.053702
P577
2009-02-11T00:00:00Z