p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
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Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesisRetinoblastoma family genesReduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cellsU94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3.Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cellsA mechanism misregulating p27 in tumors discovered in a functional genomic screen.Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas.A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity.Genetically engineered mouse models of pituitary tumorsWide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.Mouse models of endocrine tumours.ARF mutation accelerates pituitary tumor development in Rb+/- mice.Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1The pathogenesis of pituitary tumours.Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritisDeregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia.Pituitary hyperplasia in glycoprotein hormone alpha subunit-, p18(INK4C)-, and p27(kip-1)-null mice: analysis of proteins influencing p27(kip-1) ubiquitin degradationp21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis.Skp2 is oncogenic and overexpressed in human cancersE2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomasCell cycle in mouse development.Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation.Transcriptional control of cell-cycle quiescence during C. elegans development.Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations.The non-canonical functions of p27(Kip1) in normal and tumor biology.Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation.P21 and p27: roles in carcinogenesis and drug resistance.The notch target gene HES1 regulates cell cycle inhibitor expression in the developing pituitary.The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.p27kip1: a new multiple endocrine neoplasia gene?Thyroid C-Cell Biology and Oncogenic Transformation.Retinoblastoma protein is frequently absent or phosphorylated in anaplastic large-cell lymphoma.p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.IFN-gamma/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer.RB2/p130 ectopic gene expression in neuroblastoma stem cells: evidence of cell-fate restriction and induction of differentiation
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p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1999
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
@en
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
@nl
type
label
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
@en
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
@nl
prefLabel
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
@en
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
@nl
P2093
P2860
P356
P1476
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice
@en
P2093
C Cordon-Cardo
H T Nguyen
P Capodieci
P2860
P304
P356
10.1073/PNAS.96.11.6382
P407
P50
P577
1999-05-01T00:00:00Z