Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules.
about
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC moleculePeptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display librariesThe CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.Direct evidence for native CD4 oligomers in lymphoid and monocytoid cells.Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.Modulation of CD4 T cell function by soluble MHC II-peptide chimeras.The role of charge and multiple faces of the CD8 alpha/alpha homodimer in binding to major histocompatibility complex class I molecules: support for a bivalent model.A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeuticsThe two membrane proximal domains of CD4 interact with the T cell receptor.Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex bindingThe human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.Protein/peptide-based entry/fusion inhibitors as anti-HIV therapies: challenges and future direction.Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human immunodeficiency virus.A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.Prediction of the secondary structure of HIV-1 gp120.Identification of a human CD4-CDR3-like surface involved in CD4+ T cell function.Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.Immunoglobulin superfamily proteins: structure, mechanisms, and drug discovery.T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.Distribution of the CD4 Alleles in Sus scrofa Demonstrates the Genetic Profiles of Western Breeds and Miniature Pigs.Identification of the CD8 DE loop as a surface functional epitope. Implications for major histocompatibility complex class I binding and CD8 inhibitor design.Impact of a CD4 gene haplotype on the immune response in minipigs.A5, a new small-molecule inhibitor of CD4 D1 obtained from a computer-aided screening method, contributes to the inhibition of CD4+ T-cell function.
P2860
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P2860
Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Human immunodeficiency virus g ...... mpatibility complex molecules.
@en
Human immunodeficiency virus g ...... mpatibility complex molecules.
@nl
type
label
Human immunodeficiency virus g ...... mpatibility complex molecules.
@en
Human immunodeficiency virus g ...... mpatibility complex molecules.
@nl
prefLabel
Human immunodeficiency virus g ...... mpatibility complex molecules.
@en
Human immunodeficiency virus g ...... mpatibility complex molecules.
@nl
P2093
P2860
P356
P1476
Human immunodeficiency virus g ...... mpatibility complex molecules.
@en
P2093
E L Reinherz
L K Clayton
S C Harrison
P2860
P304
12008-12012
P356
10.1073/PNAS.89.24.12008
P407
P577
1992-12-01T00:00:00Z