Rac1 is required for cardiomyocyte apoptosis during hyperglycemia. - Wikidata - wikimedia - TriplyDB

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

http://www.wikidata.org/entity/Q37360478

about

MicroRNA dysregulation in diabetic ischemic heart failure patients Diabetic Cardiovascular Disease Induced by Oxidative Stress Over-nutrition and metabolic cardiomyopathy NADPH oxidases in heart failure: poachers or gamekeepers?Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies High glucose-mediated oxidative stress impairs cell migration.Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy Molecular mechanistic associations of human diseases Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes.Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy.Novel aspects of the roles of Rac1 GTPase in the cardiovascular system Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes.Diabetic cardiomyopathy, causes and effects.Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP.Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches MicroRNAs involved in the mitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy.EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells.Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.Updating experimental models of diabetic cardiomyopathy Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation.Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice.Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart.Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction.Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.Inhibition of Rac1 reduces store overload-induced calcium release and protects against ventricular arrhythmia Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.Therapeutic properties of Scutellaria baicalensis in db/db mice evaluated using Connectivity Map and network pharmacology.NADPH oxidases and cardiac remodelling.Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets.Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease.ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes.

P2860

Q24618462-B93713FE-1E46-4B1A-8EE9-A7735E96DAB3 Q26778017-BAAE7808-8118-4349-A913-ECBEF68E8A13 Q27000683-DEAE0C4D-6B52-481A-9EA5-BF6A6068E000 Q27001094-E2DD746E-DB95-4D98-ABBE-0C2C5D52055B Q27002459-5DB65A1B-F40F-4729-9F9A-80D2CB370A69 Q27329542-07D4FE45-C344-42B6-BFA7-D2FD1279DF56 Q28385804-EDFB971E-E9AE-42AA-8614-54EA17488CFC Q28391746-8061356A-C5DE-426B-955C-76B5FF1396D8 Q28397064-628B108D-69C6-49A9-AB94-2FFC4271168A Q30496754-53FBF1FD-31EA-4101-B7B2-B25D77EEB378 Q33712788-D2FFADEA-790D-45BE-AE45-3AE1C7621E61 Q33740554-CFCC3FB9-9183-4664-8A20-7A77CD00D996 Q33746458-7869E7DC-2E49-4523-A78F-19FD049AA90D Q33899819-9DCF9026-C6A5-44D5-861D-E577E209FB50 Q34024314-5E541FA6-46A3-4CCB-8FB9-73854C02826A Q34038623-7A385099-44BE-4538-943C-7DAE50FE9EFD Q34055584-93C5F927-11BB-47D1-BEED-309A2B207B38 Q34062711-BAC69AED-3D7E-4EE1-95CD-095AE7018201 Q34311221-4A1CC17D-554E-4683-96C7-2C1DD7A39BF9 Q34594368-5AB1472F-63DD-4287-9715-2E84DEB6684F Q34777763-6570E132-3665-4FA7-A94F-5196C4793982 Q35167928-CC9CC451-02C6-4324-9070-3A3102AE0BF0 Q35236262-D0F4CD13-2E39-4E98-A25A-F92EFDFCA31D Q35404856-5BA3003C-818F-46DC-93F4-39E3FF1C136E Q35564129-41763714-230B-4221-8338-BFF3C243429A Q35773719-8F05A7E1-FC30-4C26-B388-7CE1D6D46A75 Q35843423-7967503C-5BCD-44C9-AD99-30A7977CB584 Q35922922-E578EA7E-98CD-4A84-8A69-DF8EBA9CD08E Q36022159-C62771E0-B9ED-451B-AD00-714DC99FEFD4 Q36201829-7F4A5DEC-BCF0-494D-A101-26B4BE20E02F Q36528029-7ACA8CBA-E444-4B48-9429-23493EE47B4C Q36632912-CDD489B1-D9FC-42C0-921F-92C44D83E275 Q36816577-655BF146-FC23-4941-B31A-50169E7F91EF Q37117160-D68810C8-BB54-4FA6-870B-DC34156CEBEF Q37609275-6A0437E9-682F-4F8E-B9E8-A2262FDCE151 Q37615239-7C409D5A-AE9B-448F-BBCC-20996378CA23 Q37775558-793FDA66-B9D4-4885-A48E-3A667C5F0B48 Q37832957-E9E67808-35EE-4C7E-94C7-9C80685E1281 Q38072297-26C81C7A-A9E1-41BB-8A18-8ECBEE70B581 Q38729174-D1AB2CF1-AE07-4AA9-84E2-92BCAA2840F4

P2860

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

http://www.wikidata.org/entity/Q37360478

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 10 July 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

@en

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

@nl

type

label

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

@en

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

@nl

prefLabel

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

@en

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

@nl

P1433

Q37360478-943E29FA-D531-44AE-BD3D-41B4FFDCB4E0

P1476

Q37360478-5F5A2720-EFC9-4733-B88E-17BE0086B29C

P2093

Q37360478-011C29C5-B725-48C6-B3E2-3AA2344E10A0

Q37360478-01717BF1-CBA7-442A-8056-61B9B60BC786

Q37360478-4410E2B4-FEA8-4FA4-B448-DDDFE34955E7

Q37360478-45ED3BD2-0393-4D9E-A868-53FEE4ED1339

Q37360478-57B06B1A-EF7B-44CA-BE83-1CA3B787CB89

Q37360478-786A5C9B-7DB7-463F-958A-F2B187340A3D

Q37360478-86E6F8E6-9B48-49E8-B8D3-25E2AD35764B

Q37360478-B3F69528-EA66-40C0-9C03-AD2999BE939C

P2860

Q37360478-0139D4E8-2169-4838-AF61-AC1E1AC978D1

Q37360478-0A7CF8B7-C92C-4582-9EAA-6636BA684E1C

Q37360478-1278D1D6-6949-475B-A3ED-7DB018E53367

Q37360478-1B4B15B9-7CDA-4C68-8132-D4919AC6E23B

Q37360478-1CAF5027-F5CC-4E8D-A300-E6259A5F3BF9

Q37360478-1E41F689-178A-4891-9B60-BDBD27D4CAAC

Q37360478-29EF4B7A-E6A2-4CB0-BC3C-46EC211676A2

Q37360478-2D10D411-6789-42E5-AE1E-04E414002F72

Q37360478-3045FE77-48D4-40FF-92DD-091D70AB727B

Q37360478-3183B85A-2C47-4E8E-9B11-5ADAA7097677

P304

Q37360478-AA83FE03-FA9E-4A02-B3CB-C33ECC1CCF25

P31

Q37360478-30DA3587-DB20-41E0-8855-0AB94B2F6334

P356

Q37360478-7D0BBA6D-9D5F-424A-845B-43B07516D239

P407

Q37360478-0FADB270-BAFD-4998-8BA7-0BB5A45AFA3B

P433

Q37360478-D951C096-D555-47B0-AB2B-E2DD34518C4F

P478

Q37360478-2049367B-6EC0-4D60-9F20-C21EEB94F655

P577

Q37360478-59641DEF-85A4-4B14-B097-6523912E09FA

P5875

Q37360478-39DBA3A7-A77A-449D-9D10-1E613227397B

P698

Q37360478-B3A53FC5-810A-4D49-A395-F7D5CBB0DEDE

P921

Q37360478-5624527F-A338-4561-9D71-17FEC2AC778E

Q37360478-B1BDD024-E1B4-4A96-AEF4-C895867629F4

P932

Q37360478-4460B7D6-128A-4B09-8908-EFC0E966085E

P356

P1433

P1476

Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

@en

P2093

E Shen

http://www.w3.org/2001/XMLSchema#string

Huaqing Zhu

http://www.w3.org/2001/XMLSchema#string

J Malcolm O Arnold

http://www.w3.org/2001/XMLSchema#string

Limei Shan

http://www.w3.org/2001/XMLSchema#string

Qingping Feng

http://www.w3.org/2001/XMLSchema#string

Tianqing Peng

http://www.w3.org/2001/XMLSchema#string

Yanwen Li

http://www.w3.org/2001/XMLSchema#string

Ying Li

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of RAC3, a novel member of the Rho family

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology.

The neutrophil NADPH oxidase.

Requirement of Rac1 in the development of cardiac hypertrophy.

Cell death and diabetic cardiomyopathy.

Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: a short review.

P304

2386-2395

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.2337/DB08-0617

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

58

http://www.w3.org/2001/XMLSchema#string

P577

2009-07-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26661565

http://www.w3.org/2001/XMLSchema#string

P698

19592621

http://www.w3.org/2001/XMLSchema#string

P921

apoptotic process

P932

2750234

http://www.w3.org/2001/XMLSchema#string