Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.
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Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon RegenerationRemyelination Therapy in Multiple SclerosisSeizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in miceKif14 mutation causes severe brain malformation and hypomyelinationOligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brainLysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular ToxicityRegulatory mechanisms that mediate tenascin C-dependent inhibition of oligodendrocyte precursor differentiationMicroRNA-23a promotes myelination in the central nervous systemNudging oligodendrocyte intrinsic signaling to remyelinate and repair: Estrogen receptor ligand effects.Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis.Estrogen receptor (ER) β expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligandNeurodevelopmental effects of insulin-like growth factor signaling.Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination.Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.Neural stem cell engraftment and myelination in the human brain.Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways.PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury.Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons.In situ fluorescence imaging of myelinationAdenosine triphosphate promotes locomotor recovery after spinal cord injury by activating mammalian target of rapamycin pathway in ratsCyclin-dependent kinase 5 mediates adult OPC maturation and myelin repair through modulation of Akt and GsK-3β signaling.Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation.Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelinationWhite matter alterations in bipolar disorder: potential for drug discovery and development.Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNSRole of ERK1/2 MAPK signaling in the maintenance of myelin and axonal integrity in the adult CNS.Evaluation of the impact of the cancer therapy everolimus on the central nervous system in miceA novel PET marker for in vivo quantification of myelination.Longitudinal near-infrared imaging of myelination.Rheb1 is required for mTORC1 and myelination in postnatal brain developmentActivation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegenerationMultiple functional therapeutic effects of the estrogen receptor β agonist indazole-Cl in a mouse model of multiple sclerosisHuman glial-restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination.The thrombin receptor is a critical extracellular switch controlling myelination.The myelin brake: when enough is enough.Visual abnormalities associated with enhanced optic nerve myelinationInteraction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation.Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.
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Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Akt signals through the mammal ...... y to regulate CNS myelination.
@en
Akt signals through the mammal ...... y to regulate CNS myelination.
@nl
type
label
Akt signals through the mammal ...... y to regulate CNS myelination.
@en
Akt signals through the mammal ...... y to regulate CNS myelination.
@nl
prefLabel
Akt signals through the mammal ...... y to regulate CNS myelination.
@en
Akt signals through the mammal ...... y to regulate CNS myelination.
@nl
P2093
P2860
P1476
Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination
@en
P2093
Ana I Flores
Wendy B Macklin
P2860
P304
P356
10.1523/JNEUROSCI.0232-09.2009
P407
P577
2009-05-01T00:00:00Z