Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
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Nitro-fatty acids: novel anti-inflammatory lipid mediatorsStructure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDODiscovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agentsSmall molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsThe complexity of the Nrf2 pathway: beyond the antioxidant responseEmerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotectionInduction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone AActivation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formationScreening for natural chemoprevention agents that modify human Keap1.Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1Crystal structure of KLHL3 in complex with Cullin3Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.Modification of keap1 cysteine residues by sulforaphane.Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease preventionHepatic stem cells and transforming growth factor β in hepatocellular carcinomaIn vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathwayCullin 3 as a novel target in diverse pathologiesThe Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock ResponseThe cytoprotective role of the Keap1-Nrf2 pathway.Monitoring Keap1-Nrf2 interactions in single live cells.Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.The Chemistry of Gut Microbial Metabolism of Polyphenols.Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.Nrf2-a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke.The Role of Glucosinolate Hydrolysis Products from Brassica Vegetable Consumption in Inducing Antioxidant Activity and Reducing Cancer Incidence.Validation of the multiple sensor mechanism of the Keap1-Nrf2 systemNrf2, the Master Regulator of Anti-Oxidative Responses.Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation.Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway.Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells.Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships.KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane.Keap1-Nrf2 pathway: A promising target towards lung cancer prevention and therapeutics.Systems-Level Feedbacks of NRF2 Controlling Autophagy upon Oxidative Stress Response.p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases
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Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cul3-mediated Nrf2 ubiquitinat ...... lume at position 151 of Keap1.
@en
Cul3-mediated Nrf2 ubiquitination and antioxidant response element
@nl
type
label
Cul3-mediated Nrf2 ubiquitinat ...... lume at position 151 of Keap1.
@en
Cul3-mediated Nrf2 ubiquitination and antioxidant response element
@nl
prefLabel
Cul3-mediated Nrf2 ubiquitinat ...... lume at position 151 of Keap1.
@en
Cul3-mediated Nrf2 ubiquitination and antioxidant response element
@nl
P2860
P356
P1433
P1476
Cul3-mediated Nrf2 ubiquitinat ...... lume at position 151 of Keap1.
@en
P2093
Evan Small
Mark Hannink
P2860
P304
P356
10.1042/BJ20090471
P407
P577
2009-07-29T00:00:00Z