Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
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Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathwayCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonIsolation of the thrombospondin membrane receptorThrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activationChromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIaInteractions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responsesLateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3Purification and partial characterization of CD9 antigen of human plateletsAdhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAKBinding strength and activation state of single fibrinogen-integrin pairs on living cells.Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Novel platelet-agglutinating protein from a thrombotic thrombocytopenic purpura plasma.A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIaGlanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb.Adenosine diphosphate-induced aggregation of human platelets in flow through tubes. II. Effect of shear rate, donor sex, and ADP concentrationActivation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombastheniaThrombospondin-induced adhesion of human platelets.Agkistrodon piscivorus piscivorus platelet aggregation inhibitor: a potent inhibitor of platelet activation.Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function.Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force.A myeloma paraprotein with specificity for platelet glycoprotein IIIa in a patient with a fatal bleeding disorder.Functionally thrombasthenic state in normal platelets following the administration of ticlopidine.Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia.Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody.von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia.Presence of complement-fixing anti-endothelial cell antibodies in systemic lupus erythematosus.Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets.Retention of the glycoprotein IIb-IIIa complex in the isolated platelet cytoskeleton. Effects of separable assembly of platelet pseudopodal and contractile cytoskeletons.Role of thrombospondin in platelet aggregation.Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation.Historical perspective and future directions in platelet research.Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon.Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa.Platelet glycoproteins Ia, Ic, and IIa are physicochemically indistinguishable from the very late activation antigens adhesion-related proteins of lymphocytes and other cell types.Decreased content and surface expression of alpha-granule membrane protein GMP-140 in one of two types of platelet alpha delta storage pool deficiency.The human platelet fibrinogen receptor: clinical and therapeutic significance.Development of glycoprotein IIb-IIIa antagonists: translation of pharmacodynamic effects into clinical benefit.
P2860
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P2860
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
@en
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
@nl
type
label
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
@en
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
@nl
prefLabel
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
@en
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
@nl
P2093
P2860
P356
P1476
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.
@en
P2093
J S Bennett
S F Leitman
P2860
P304
P356
10.1073/PNAS.80.9.2417
P407
P577
1983-05-01T00:00:00Z