Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody.
about
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Laboratory investigation of immune thrombocytopenia.A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIaThrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets.Imaging thrombus with radiolabelled monoclonal antibody to platelets.Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function.A myeloma paraprotein with specificity for platelet glycoprotein IIIa in a patient with a fatal bleeding disorder.Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery.Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins.A monoclonal antibody to human platelet glycoprotein IIIa detects a related protein in cultured human endothelial cells.Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia.Historical perspective and future directions in platelet research.Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood.Reduced surface expression and binding of fibronectin by thrombin-stimulated thrombasthenic platelets.Gray platelet syndrome. Demonstration of alpha granule membranes that can fuse with the cell surface.Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon.A genomic clone encoding the alpha chain of the OKM1, LFA-1, and platelet glycoprotein IIb-IIIa moleculesBiogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa.A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein.Platelet-collagen adhesion: evidence for participation of antigenically distinct entities.Platelet-collagen adhesion: inhibition by a monoclonal antibody that binds glycoprotein IIb.Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa.alpha-Actinin and membrane glycoprotein IIIa are different proteins in human blood platelets.Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytesThrombin-induced platelet membrane glycoprotein IIb and IIIa complex formation. An electron microscope study.In vitro studies of human pluripotential hematopoietic progenitors in polycythemia vera. Direct evidence of stem cell involvement.Complex formation of platelet thrombospondin with fibrinogenComplex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen.Glanzmann thrombasthenia. Cooperation between sequence variants in cis during splice site selection.Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells.A monoclonal anti-platelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets.Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.The phosphatidylinositol pathway of platelets and vascular cells.Glycoprotein IIb-IIIa content and platelet aggregation in healthy volunteers and patients with acute coronary syndrome.Evaluation of hemostasis in flowing blood.The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.New isolation procedure and further biochemical characterization of glycoproteins IIb and IIIa from human platelet plasma membrane.The role of protein phosphorylation and cytoskeletal reorganization in microparticle formation from the platelet plasma membraneFurther studies on the topography of human platelet glycoprotein IIb. Localization of monoclonal antibody epitopes and the putative glycoprotein IIa- and fibrinogen-binding regions.Fibrin clot retraction by human platelets correlates with alpha(IIb)beta(3) integrin-dependent protein tyrosine dephosphorylation.
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P2860
Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1980
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Isolation and quantitation of ...... monoclonal hybridoma antibody.
@en
Isolation and quantitation of ...... monoclonal hybridoma antibody.
@nl
type
label
Isolation and quantitation of ...... monoclonal hybridoma antibody.
@en
Isolation and quantitation of ...... monoclonal hybridoma antibody.
@nl
prefLabel
Isolation and quantitation of ...... monoclonal hybridoma antibody.
@en
Isolation and quantitation of ...... monoclonal hybridoma antibody.
@nl
P2093
P2860
P356
P1476
Isolation and quantitation of ...... monoclonal hybridoma antibody.
@en
P2093
N L Baenziger
P W Majerus
R P McEver
P2860
P304
P356
10.1172/JCI109983
P407
P577
1980-12-01T00:00:00Z