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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.

The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.

http://www.wikidata.org/entity/Q37644606

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Therapeutic targets in age-related macular disease Complement in age-related macular degeneration: a focus on function AMD and the alternative complement pathway: genetics and functional implications Stem Cell Therapy for Treatment of Ocular Disorders Relationship between Oxidative Stress, Circadian Rhythms, and AMD Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers Inflammation and its role in age-related macular degeneration Parainflammation, chronic inflammation, and age-related macular degeneration Dementia of the eye: the role of amyloid beta in retinal degeneration Genetics of immunological and inflammatory components in age-related macular degeneration NLRP3 inflammasome: activation and regulation in age-related macular degeneration The proteomics of drusen Mechanisms of age-related macular degeneration Genetic variants in the complement system predisposing to age-related macular degeneration: a review Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD)Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis.Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury Recent developments in the management of dry age-related macular degeneration CEP biomarkers as potential tools for monitoring therapeutics Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis Age-related alterations in retinal neurovascular and inflammatory transcripts Age-related macular degeneration and the incidence of cardiovascular disease: a systematic review and meta-analysis Soluble CD59 expressed from an adenovirus in vivo is a potent inhibitor of complement deposition on murine liver vascular endothelium Complement: a key system for immune surveillance and homeostasis Polymodal Sensory Integration in Retinal Ganglion Cells.Design of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: the case of C3 inhibition by compstatin Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment.A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice Autoimmunity: homeostasis of innate immunity gone awry.Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation.Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells The complexities underlying age-related macular degeneration: could amyloid beta play an important role?Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions.Immune responses in age-related macular degeneration and a possible long-term therapeutic strategy for prevention Differential gene expression in glaucoma Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium A computational and experimental study of the regulatory mechanisms of the complement system

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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.

http://www.wikidata.org/entity/Q37644606

description

article científic

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artigo científico

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bilimsel makale

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scientific article published on 02 December 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The pivotal role of the comple ...... ration: hypothesis re-visited.

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The pivotal role of the comple ...... ration: hypothesis re-visited.

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The pivotal role of the comple ...... ration: hypothesis re-visited.

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The pivotal role of the comple ...... ration: hypothesis re-visited.

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The pivotal role of the comple ...... ration: hypothesis re-visited.

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J.PRETEYERES.2009.11.003

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Progress in Retinal and Eye Research

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The pivotal role of the comple ...... ration: hypothesis re-visited.

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Catherine Bowes Rickman

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Christy R Curletti

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Dean Bok

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Don H Anderson

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Ethan A Chapin

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Goldis Malek

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Gregory S Hageman

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Jane Hu

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Jessica N Ebright

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Lincoln V Johnson

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P2860

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Complement factor H polymorphism in age-related macular degeneration

Variation near complement factor I is associated with risk of advanced AMD

The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas

Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes

C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity

Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

Complement factor H variant increases the risk of age-related macular degeneration

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95-112

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scholarly article

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10.1016/J.PRETEYERES.2009.11.003

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2009-12-02T00:00:00Z

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19961953

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