about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerMutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfismA microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targetingInsights into APC/C: from cellular function to diseases and therapeuticsThe Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisKNL1: bringing order to the kinetochoreThree wise centromere functions: see no error, hear no break, speak no delayLoss of the Greatwall Kinase Weakens the Spindle Assembly CheckpointARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochoresExcess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivoCep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2.Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cellsElectron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdownMad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint.Anaphase BDeficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instabilityLooping in on Ndc80 - how does a protein loop at the kinetochore control chromosome segregation?Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis.An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes.Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylationThe Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle OrientationExpression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy.Chromosome segregation in plant meiosis.The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregationCENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control.Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast.A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Expression and function analysis of mitotic checkpoint genes identifies TTK as a potential therapeutic target for human hepatocellular carcinoma.IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma.RanGTP aids anaphase entry through Ubr5-mediated protein turnover.Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturationAn assay to detect in vivo Y chromosome loss in Drosophila wing disc cells.Lack of response to unaligned chromosomes in mammalian female gametes.DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint.Nucleolar asymmetry and the importance of septin integrity upon cell cycle arrestAntagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregationProbing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Spindle assembly checkpoint: the third decade.
@en
Spindle assembly checkpoint: the third decade.
@nl
type
label
Spindle assembly checkpoint: the third decade.
@en
Spindle assembly checkpoint: the third decade.
@nl
prefLabel
Spindle assembly checkpoint: the third decade.
@en
Spindle assembly checkpoint: the third decade.
@nl
P2860
P356
P1476
Spindle assembly checkpoint: the third decade.
@en
P2860
P304
P356
10.1098/RSTB.2011.0072
P407
P577
2011-12-01T00:00:00Z
2011-12-27T00:00:00Z