DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2.
about
Inhibitors of human immunodeficiency virus integraseIdentification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical libraryRetroviral DNA IntegrationDissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysisMapping viral DNA specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteinsEfficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 integrase.A map of interactions between the proteins of a retrotransposonTargeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1.Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.The application of a homologous recombination assay revealed amino acid residues in an LTR-retrotransposon that were critical for integration.Retroviral integrase proteins and HIV-1 DNA integrationIncorporation of a fluorescent guanosine analog into oligonucleotides and its application to a real time assay for the HIV-1 integrase 3'-processing reactionExpression and partial purification of enzymatically active recombinant Ty1 integrase in Saccharomyces cerevisiaeHIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.Characterization of recombinant murine leukemia virus integrase.Monoclonal antibodies against Rous sarcoma virus integrase protein exert differential effects on integrase function in vitroMapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases.Sequences in the human immunodeficiency virus type 1 U3 region required for in vivo and in vitro integration.Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesisInhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions.Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysisReversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivityFunctional identification of nucleotides conferring substrate specificity to retroviral integrase reactions.Human immunodeficiency virus type 2 preintegration complexes: activities in vitro and response to inhibitors.Folding of the multidomain human immunodeficiency virus type-I integraseThe molecular biology of HIV integrase.Genetic analysis of the human immunodeficiency virus type 1 integrase protein.In vitro activities of purified visna virus integraseDetection and characterization of a functional complex of human immunodeficiency virus type 1 integrase and its DNA substrate by UV cross-linking.The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding.Juxtaposition of two viral DNA ends in a bimolecular disintegration reaction mediated by multimers of human immunodeficiency virus type 1 or murine leukemia virus integrase.Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.Integration of human immunodeficiency virus DNA: adduct interference analysis of required DNA sitesDynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.Requirement for a conserved serine in both processing and joining activities of retroviral integrase.Mutational analysis of the integrase protein of human immunodeficiency virus type 2.
P2860
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P2860
DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
DNA binding properties of the ...... iciency viruses types 1 and 2.
@en
type
label
DNA binding properties of the ...... iciency viruses types 1 and 2.
@en
prefLabel
DNA binding properties of the ...... iciency viruses types 1 and 2.
@en
P2093
P2860
P356
P1476
DNA binding properties of the ...... iciency viruses types 1 and 2.
@en
P2093
P2860
P304
P356
10.1093/NAR/19.14.3821
P407
P577
1991-07-01T00:00:00Z