Chemical trapping of ternary complexes of human immunodeficiency virus type 1 integrase, divalent metal, and DNA substrates containing an abasic site. Implications for the role of lysine 136 in DNA binding.
about
Identification of a nucleotide binding site in HIV-1 integraseCovalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites.Proteomic approach to identification of proteins reactive for abasic sites in DNA.Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA bindingGenetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.Mapping viral DNA specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteinsUse of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selectionRelationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity.Recent advances in the investigation of curcuminoids.Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitorsHIV-1 Integrase-DNA Recognition Mechanisms.Mapping DNA-binding sites of HIV-1 integrase by protein footprinting.Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.Probing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA.Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates.Inhibiting the HIV integration process: past, present, and the future.Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase.Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop.
P2860
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P2860
Chemical trapping of ternary complexes of human immunodeficiency virus type 1 integrase, divalent metal, and DNA substrates containing an abasic site. Implications for the role of lysine 136 in DNA binding.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Chemical trapping of ternary c ...... of lysine 136 in DNA binding.
@en
type
label
Chemical trapping of ternary c ...... of lysine 136 in DNA binding.
@en
prefLabel
Chemical trapping of ternary c ...... of lysine 136 in DNA binding.
@en
P2093
P2860
P356
P1476
Chemical trapping of ternary c ...... of lysine 136 in DNA binding.
@en
P2093
P2860
P304
27330-27338
P356
10.1074/JBC.271.44.27330
P407
P577
1996-11-01T00:00:00Z