A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro
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HIV-1 integrase crosslinked oligomers are active in vitroHuman immunodeficiency virus type 1 preintegration complexes: studies of organization and compositionStructure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes.Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolitesDifferential inhibition of HIV-1 preintegration complexes and purified integrase protein by small moleculesLocalization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysisUnprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravirEngineered hyperactive integrase for concerted HIV-1 DNA integrationDissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysisNucleophile selection for the endonuclease activities of human, ovine, and avian retroviral integrases.Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody.Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids.Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation.HIV-1 IN inhibitors: 2010 update and perspectivesA family of developmentally excised DNA elements in Tetrahymena is under selective pressure to maintain an open reading frame encoding an integrase-like proteinIn vitro integration of human immunodeficiency virus type 1 cDNA into targets containing protein-induced bendsUse of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selectionAvian retrovirus DNA internal attachment site requirements for full-site integration in vitroCritical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.Transposase makes critical contacts with, and is stimulated by, single-stranded DNA at the P element termini in vitro.Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.Methods for integration site distribution analyses in animal cell genomesBiochemical characteristics of functional domains using feline foamy virus integrase mutantsDiketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/M154I catalytic domain.Metal binding by the D,DX35E motif of human immunodeficiency virus type 1 integrase: selective rescue of Cys substitutions by Mn2+ in vitroRetroviral DNA integration: reaction pathway and critical intermediates.Discovery of a small-molecule HIV-1 integrase inhibitor-binding siteAllosteric inhibitor development targeting HIV-1 integrase.Targeting HIV-1 integrase.HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA.Characterization of recombinant murine leukemia virus integrase.Different roles of bases within the integration signal sequence of human immunodeficiency virus type 1 in vitro.Mapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases.Concerted integration of retrovirus-like DNA by human immunodeficiency virus type 1 integrase.Assembly and catalytic properties of retrovirus integrase-DNA complexes capable of efficiently performing concerted integration.Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping and differential effects on integrase activities in vitroCoordinated disintegration reactions mediated by Moloney murine leukemia virus integrase.
P2860
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P2860
A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
A stable complex between integ ...... ncy virus integration in vitro
@ast
A stable complex between integ ...... ncy virus integration in vitro
@en
type
label
A stable complex between integ ...... ncy virus integration in vitro
@ast
A stable complex between integ ...... ncy virus integration in vitro
@en
prefLabel
A stable complex between integ ...... ncy virus integration in vitro
@ast
A stable complex between integ ...... ncy virus integration in vitro
@en
P2860
P356
P1476
A stable complex between integ ...... ncy virus integration in vitro
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.15.7316
P407
P577
1994-07-01T00:00:00Z